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MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
ProteomicsAnalysing the Mechanism of Mitochondrial Oxidation-induced Cell Death Using a Multifunctional Iridium(III) Photosensitiser
Mitochondrial oxidation-induced cell death, a physiological process triggered by various cancer therapeutics to induce oxidative stress on tumours, has been challenging to investigate owing to the difficulties in generating mitochondria-specific oxidative stress and monitoring mitochondrial response...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD022163 | Pride
Photosensitiser Iridium(iii) complex Mitochondrial oxidation-induced cell death Photo-crosslinking Depolarisation 
TranscriptomicsSkeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.
Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical t...
ORGANISM(S): Mus musculus 
2012-02-04 | E-GEOD-34773 | biostudies-arrayexpress
UnknownAnalysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser.
Not available
S-EPMC7782791 | biostudies-literature
TranscriptomicsExtensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells (miRNA)
Understanding toxicity pathways of engineered nanomaterials (ENM) has recently been brought forward as a key step in 21st century ENM risk assessment. Molecular mechanisms linked to phenotypic end points is a step towards the development of toxicity tests based on key events, which may allow for gro...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-63559 | biostudies-arrayexpress
TranscriptomicsExtensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells (Affymetrix)
Understanding toxicity pathways of engineered nanomaterials (ENM) has recently been brought forward as a key step in 21st century ENM risk assessment. Molecular mechanisms linked to phenotypic end points is a step towards the development of toxicity tests based on key events, which may allow for gro...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-63552 | biostudies-arrayexpress
UnknownRestoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury.
Not available
S-EPMC9768173 | biostudies-literature
UnknownGranzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
Not available
S-EPMC2840390 | biostudies-literature
UnknownHyperoxidation of mitochondrial peroxiredoxin limits H2 O2 -induced cell death in yeast.
Not available
S-EPMC6745495 | biostudies-literature
UnknownFas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.
Not available
S-EPMC5589858 | biostudies-literature
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