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ProteomicsDisrupting CISD2 function in cancer cells primarily alters mitochondrial labile iron status and triggers reactive oxygen species accumulation
The multiple functions of CISD2 in cells could result from its role in calcium signaling, iron and/or iron-sulfur homeostasis, and/or ROS signaling/homeostasis. The relationship(s) and interdependency between these different signaling and homeostasis processes are however unclear at present, since m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087436 | MassIVE
GenomicsMetabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
PRJNA663327 | ENA
ProteomicsTargeting mitochondrial reactive oxygen species alleviates allergic airway disease in a mouse model of obese allergic asthma
Obesity is associated with severe, difficult to control asthma, and increased airway oxidative stress. Mitochondrial reactive oxygen species (mROS) are an important source of oxidative stress leading us to hypothesize that targeting mROS in obese allergic asthma might be an effective treatment strat...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2023-06-02 | PXD029715 | Pride
Obesity Mitochondrial reactive oxygen species (mros) Allergic asthma Airway oxidome Unfolded protein response (upr). Mitoquinone Tissue eosinophilia 
TranscriptomicsMetabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused ...
ORGANISM(S): Homo sapiens 
2020-09-15 | GSE157912 | GEO
ProteomicsPHF8 Demethylates YY1 to Regulate ETC Gene and mROS to Promote Cancer Cell Growth
High levels of mitochondrial reactive oxygen species (mROS) are linked to cancer development, which is tightly controlled by electron transport chain (ETC). Targeting ETC represents a promising way of curing cancers. However, the epigenetic mechanisms governing ETC gene transcription to drive mROS p...
ORGANISM(S): Homo Sapiens 
PXD034400 |
UnknownMetabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.
Not available
S-EPMC7673681 | biostudies-literature
GenomicsPHF8 Demethylates YY1 to Regulate Electron Transfer Chain Gene Transcription and License Mitochondrial Reactive Oxygen Species Production to Promote Cancer Cell Growth
Emerging evidence suggest that mitochondrial reactive oxygen species (mROS) production is tightly controlled by electron transport chain (ETC), and increased levels of ROS production is linked to cancer development. The ETC therefore represents a promising way of cancer treatment. However, the epige...
ORGANISM(S): Homo sapiens 
2024-10-06 | GSE185244 | GEO
UnknownProtein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.
Not available
S-EPMC1265746 | biostudies-literature
TranscriptomicsThe Core Subunit NDUFS2 in Mitochondrial Complex I is Critical to Oxygen Sensing in Human Ductus Arteriosus Smooth Muscle Cells
Rationale: Mitochondria in ductus arteriosus smooth muscle cells (DASMC) are oxygen sensors triggering vasoconstriction at birth; however, the mitochondrial oxygen sensing mechanisms are not fully understood. Given the conserved role of mitochondrial Complex I subunit NDUFS2 in other oxygen-sensing ...
ORGANISM(S): Homo sapiens 
2026-07-27 | GSE335748 | GEO
GenomicsPHF8 Demethylates YY1 to Regulate Electron Transfer Chain Gene Transcription and License Mitochondrial Reactive Oxygen Species Production to Promote Cancer Cell Growth
PHF8 Demethylates YY1 to Regulate Electron Transfer Chain Gene Transcription and License Mitochondrial Reactive Oxygen Species Production to Promote Cancer Cell Growth
PRJNA768390 | ENA
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