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MetabolomicsFate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics.
The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Re...
2024-02-07 | MTBLS4063 | MetaboLights
MetabolomicsHydrolyzing NAD to NMN and AMP by SelO is required for mitochondria homeostasis

The regulation of mitochondrial nicotinamide adenine dinucleotide (mNAD) is crucial for numerous life processes. However, until now, no metabolic reaction responsible for downregulating mNAD has been identified. Through in silico screening of potential NAD-binding proteins, we discovered a previo...

2026-01-07 | MTBLS13624 | MetaboLights
MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
ProteomicsAIM32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control
Maintaining redox homeostasis under normal and stress conditions in the mitochondrion is complex. We used mass spectrometry analysis to identify key proteins that interacted with the sulfhydryl oxidase Erv1 of the mitochondrial intermembrane space assembly (MIA) pathway. Results: Aim32, a thioredoxi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-16 | PXD021662 | Pride
Aim32 Oxa1 Mitochondrion is complex. mass spectrometry Tim23 Tim22 
MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
ProteomicsCFAP418 participates in membrane-associated cellular processes through binding lipids during ciliogenesis
iliopathies and retinal degenerative diseases are heterogeneous groups of genetic diseases. CFAP418 is a causative gene of both diseases, and its sequence is evolutionarily conserved. Here, we employ affinity purification coupled with mass spectrometry and quantitative lipidomic, proteomic, and phos...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-05-05 | MSV000089424 | MassIVE
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
ProteomicsCharacterization of ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I)
This project contains MALDI-TOF/TOF spectra derived from the ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I).
ORGANISM(S): Bos Taurus 
2022-07-29 | PXD031179 | JPOST Repository
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
ProteomicsThe comparison of mitochondrial proteomics of fungal ETC Complex I mutant
Candidiasis is the most common invasive fungal infection in clinical sets. The causative agent C. albicans has a complex metabolism for energy production in which mitochondria play important roles for its virulence to the host. Three fungal- specific mitochondrial ETC complex CI subunits - Goa1p, ...
ORGANISM(S): Caenorhabditis elegans 
2017-08-16 | PXD005842 | Pride
Proteomics Oribtrap fusion ms- nano-scaled liquid chromatography Mitochondria And candida albicans 
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