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MetabolomicsTargeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...
2026-03-12 | MTBLS12512 | MetaboLights
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsMitofusin 2 expression in muscle decreases during aging and generates a gene signature characteristic of aged muscle
Mitochondrial fusion and fission proteins regulate mitochondrial quality control and mitochondrial metabolism. In turn, mitochondrial dysfunction is associated with aging, although its causes are still under debate. Here, we show that aging is characterized by a progressive reduction of Mitofusin 2 ...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71501 | biostudies-arrayexpress
UnknownExpression of mitofusin 2 in human sperm and its relationship to sperm motility and cryoprotective potentials.
Not available
S-EPMC6180404 | biostudies-literature
UnknownOPA1 requires mitofusin 1 to promote mitochondrial fusion.
Not available
S-EPMC528769 | biostudies-literature
GenomicsMitofusin agonists enhance long-term engraftment and potency of HSC cultures in vivo.
Mitofusin agonists enhance long-term engraftment and potency of HSC cultures in vivo.
PRJNA1369388 | ENA
UnknownStress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.
Not available
S-EPMC3526191 | biostudies-literature
TranscriptomicsMitofusin agonists enhance long-term engraftment and potency of HSC cultures in vivo.
Umbilical cord blood (CBU) is a valuable source of hematopoietic stem cells (HSCs) due to its superior donor compatibility and lower incidence of graft-versus-host disease. However, its limited HSC content restricts its use in adult transplantation, necessitating new targets for ex vivo expansion an...
ORGANISM(S): Homo sapiens 
2025-11-26 | GSE311386 | GEO
UnknownCorrecting mitochondrial fusion by manipulating mitofusin conformations.
Not available
S-EPMC5315023 | biostudies-literature
UnknownBack to The Fusion: Mitofusin-2 in Alzheimer's Disease.
Not available
S-EPMC7019958 | biostudies-literature
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