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MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
ProteomicsThe mitogen-activated protein kinase kinase 5 regulates the proliferation and biosynthetic processes in procyclic forms of Trypanosoma brucei
The pathogenic protozoan T. brucei alternates into distinct developmental stages in the mammalian and insect hosts. The mitogen-activated protein kinase (MAPK) signaling pathways transduce extracellular stimuli into a range of cellular responses, which ultimately lead to the adaptation to the extern...
ORGANISM(S): Trypanosoma brucei 
2017-10-20 | PXD007910 | Pride
Proteomics T. brucei Energy metabolism Phosphoproteomics Fatty acids biosynthesis Mitogen-activated protein kinase kinase 5 (mkk5) 
UnknownMitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.
Not available
S-EPMC4566985 | biostudies-literature
UnknownStructural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.
Not available
S-EPMC3605678 | biostudies-literature
ProteomicsArabidopsis thaliana proteomics/phosphoproteomics
Mitogen-activated protein kinases (MAPKs) target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited. Here, we generated transgenic Arabidopsis thaliana pla...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2014-10-20 | PXD001252 | Pride
Arabidopsis thaliana Phosphorylation Mapk Leaf Lc-ms/ms 
TranscriptomicsPKCzeta-mediated Gaq stimulation of the ERK5 pathway is involved in cardiac hypertrophy
Background: Gq-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of cardiovascular function. Enhanced Gaq-mediated signaling plays an important role in cardiac hypertrophy and in the transition to heart failure. We have recently describ...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-29145 | biostudies-arrayexpress
UnknownMKK4/5-MPK3/6 Cascade Regulates Agrobacterium-Mediated Transformation by Modulating Plant Immunity in Arabidopsis.
Not available
S-EPMC8514879 | biostudies-literature
UnknownChemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling.
Not available
S-EPMC6488365 | biostudies-literature
TranscriptomicsMEK5 is Activated by Shear Stress, Activates ERK5 And Induces KLF4 To Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells
MEK5 is activated by shear stress in large vessel endothelial cells (ECs) and contributes to the suppression of pro-inflammatory changes in the arterial wall. We used microarray analyses of total RNA from MEK5/CA-transduced HDMECs compared to LacZ control-transduced HDMECs to identify distinct class...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-25145 | biostudies-arrayexpress
UnknownDissection of MAPK signaling specificity through protein engineering in a developmental context.
Not available
S-EPMC5894206 | biostudies-literature
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