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MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Extracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1221 | MetaboLights
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1223 | MetaboLights
MetabolomicsHuaban Tongmai Decoction ameliorates carotid artery atherosclerosis by inhibiting ferroptosis via the p53-Parkin mitophagy axis

Background: Carotid artery atherosclerosis (CAS), has exhibited an increasing incidence in recent years. Although Huaban Tongmai decoction (HBTMD) shows considerable therapeutic potential against CAS, the specific molecular mechanisms of its action remain incompletely defined.

Purpose: This...

2026-02-15 | MTBLS13908 | MetaboLights
MetabolomicsGut microbial release of ferulic acid from germinated quinoa alleviates obesity-associated cognitive impairment via activation of PINK1/Parkin-mediated mitophagy in the hippocampus

Background Obesity is a major risk factor for cognitive impairment and related neurodegenerative disorders. Whole grains are rich in polyphenols and dietary fiber, and their consumption has been associated with improvements in obesity and cognitive deficits. Gut microbial genes encode enzymes tha...

2026-03-30 | MTBLS14185 | MetaboLights
MetabolomicsAtg32-mediated mitophagy promotes heat stress tolerance in Saccharomyces cerevisiae by sustaining spermidine and nitric oxide levels
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST001318 | MetabolomicsWorkbench
TranscriptomicsDefective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration (mouse)
Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA deficient cells show defective mitophagy wit...
ORGANISM(S): Mus musculus 
2015-06-04 | E-GEOD-55485 | biostudies-arrayexpress
TranscriptomicsParkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation
Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-68921 | biostudies-arrayexpress
ProteomicsKu80 interaction proteins under enhanced mitophagy
We reported Ku80 as a critical mitophagy protein and closely related to chemotherapy efficacy in liver cancer. The project detects the Ku80-interacted proteins under the condition of mitophagy activator or exogenously overexpression of Ku80 gene. After immunoprecipitation pulldown via anti-Ku80 or ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD062704 | Pride
Ku80 Mitophagy activator Liver cancer 
ProteomicsProtein import defects induce mitophagy without membrane depolarization
Upon mitochondrial dysfunction, mitophagy has been described to be activated by a breakdown of membrane potential leading to PINK1 accumulation on the outer membrane and engulfment of mitochondria for degradation. However, recent findings have indicated that mitophagy may also be triggered in the ab...
ORGANISM(S): Homo sapiens (Human) 
2022-09-03 | PXD022560 | Pride
Mitophagy Protein misfolding Mitochondrial protein import Pulsed-silac 
ProteomicsRegulation of mitophagy by Fis1 and Fascin1-organized actin
Mitophagy, the autophagic degradation of mitochondria, plays a central role in controlling the quality and quantity of mitochondria, thereby ensuring cellular health. The mitochondrial outer membrane protein Fis1 is important for several types of mitophagy, but its mechanism of action remains unclea...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-07 | PXD062948 | Pride
Mitophagy Fascin1 Fis1 Mitochondria Actin filaments 
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