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ProteomicsPhosphosites of the yeast centrosome component Spc110 contribute to mitotic exit
Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the gamma-tubulin complex to the nuclear side of SPB to form the mitotic spindle. Here we identify two phosphosites (S11 and S36) in old (from maternal origin) Spc110. Yeast expres...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-04-03 | PXD033085 | JPOST Repository
TranscriptomicsMLL and Pol2 Chip-chip in interphase and mitotic arrested cells
Mixed Lineage Leukemia (MLL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL perpetuates active transcription in dividing cells, we investigated its role during M-phase of the cell cycle. Unlike ot...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-19155 | biostudies-arrayexpress
ModelsHowell2020- Compartmental Logical model of mitotic exit
This model represents the main aspects of regulation of mitotic exit in budding yeast, including the MEN and FEAR network. As a compartmental model, it represents spatial aspects of regulation alongside regulation of enzymatic activity.
2020-11-26 | MODEL2007200001 | BioModels
ModelsQueralt2006 - Initiation of mitotic exit by downregulation of PP2A in budding yeast
Mathematical model of mitotic exit in budding yeast.
2024-09-02 | BIOMD0000000953 | BioModels
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019787 | Pride
Dephosphorylation Mitotis Mitotic exit Cell cycle Apc/c 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019788 | Pride
Dephosphorylation Phospho-proteomics Mitotic exit Cell cycle Mitosis 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019795 | Pride
Mitosis Mitotic exit Proteolysis Cell cycle Apc/c Proteome 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019791 | Pride
Proteomics Mitosis Mitotic exit Proteolysis Cell cycle Apc/c 
ProteomicsGlobal phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs
Entry into mitosis is driven by the coordinated phosphorylation of thousands of proteins. For the cell to complete mitosis and divide into two identical daughter cells it must regulate dephosphorylation of these proteins in a highly ordered, temporal manner. There is currently a lack of a complete u...
ORGANISM(S): Homo sapiens (Human) 
2015-06-25 | PXD001559 | Pride
Motif Spindle assembly checkpoint. Mitosis Phosphatase Silac Prc1 Myc Phosphorylation Mitotic exit Kinase Phosphoproteomics 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019786 | Pride
Dephosphorylation Mitosis Phospho-proteomics Mitotic exit Cell cycle Pp1 Apcc 
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