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TranscriptomicsLineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity
We used RNA-seq to compare the expression profiles of mouse prostate tumors originated from epithelial basal cells to those originated from luminal cells. We next generated expression signatures for both basal and luminal origin tumors by comparison of tumor samples to their respective controls. By ...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-39509 | biostudies-arrayexpress
TranscriptomicsIdentification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation
To investigate the role of NKX3.1 in prostate differentiation, we employed transcriptome analysis of mouse seminal vesicle (from 15-month-old Nkx3.1+/+ mice); mouse prostate (from 4-month-old Nkx3.1+/+ and Nkx3.1-/- mice); human prostate cells (RWPE1 cells engineered with empty vector (altered pTRIP...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-81440 | biostudies-arrayexpress
TranscriptomicsPredicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-69214 | biostudies-arrayexpress
TranscriptomicsIdentification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Human_RWPE1_RNA-Seq)
Analysis of transcriptome of human RWPE1 cells over-expressing wild type NKX3.1 and mutant NKX3.1 (T164A). Total RNA obtained from RWPE1 cells engineered with empty vector (altered pTRIPZ), NKX3.1 wild type over-expression, and NKX3.1 (T164A) mutant over-expression. Engineered RWPE1 cells were harve...
ORGANISM(S): Homo sapiens 
2016-06-24 | E-GEOD-81439 | biostudies-arrayexpress
TranscriptomicsIdentification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_4M-Prostate_RNA-Seq)
Analysis of transcriptome of prostate tissue from 4-month-old Nkx3.1 +/+ and Nkx3.1 -/- mice. Total RNA obtained from prostate tissues from 4-month-old Nkx3.1 +/+ and Nkx3.1 -/- mice. Prostate tissues were harvested and processed for RNA isolation and transcriptome analysis using the MagMAX RNA isol...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-81424 | biostudies-arrayexpress
TranscriptomicsIdentification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_Recomb_RNA-Seq)
Analysis of transcriptome of tissue recombinants (mouse seminal vesicle epithelial [SVE] cells or prostate epithelial [PE] cells, and rat urogenital sinus [UGS] mesenchymal cells) grown under the kidney capsule in athymic nude mice for 3 months. Total RNA obtained from tissue recombinants generated ...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-81432 | biostudies-arrayexpress
TranscriptomicsCross-species analysis of genome-wide regulatory networks identifies a synergistic dependency between FOXM1 and CENPF that drives prostate cancer malignancy
Analysis of the transcriptome of mouse models of prostate cancer to assemble a mouse prostate cancer interactome. To assemble the mouse prostate cancer interactome, we collected 13 distinct mice or genetically-engineered mouse models (GEMMs), which together represent the full spectrum of prostate ca...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-53202 | biostudies-arrayexpress
TranscriptomicsPredicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models (II)
Analysis of the transcriptome of allografted mouse tumors after treatment with rapamycin and PD0325901. Nkx3.1CreERT2/+; Ptenflox/flox; KrasLSL-G12D/+ (NPK mice) were induced and their tumors removed to generate allograft lines by implanting a 1.5 mm3 tumor fragment in the subcutaneous space of athy...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-69213 | biostudies-arrayexpress
TranscriptomicsIdentification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_15M_SV_Affy)
Analysis of transcriptome of seminal vesicle from 15-month-old Nkx3.1+/+ mice. Total RNA obtained from seminal vesicle from 15-month-old Nkx3.1+/+ mice. Seminal vesicle was harvested, RNA was extracted using Trizol (Invitrogen, Carlsbad, CA) and purified using an RNeasy kit (Qiagen, Chatsworth, CA)....
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-80600 | biostudies-arrayexpress
TranscriptomicsPredicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models (I)
Analysis of the transcriptome of mouse models of prostate cancer after treatment with rapamycin and PD0325901 combination therapy or standard of care docetaxel. The Nkx3.1CreERT2/+; Ptenflox/flox; KrasLSL-G12D/+ (NPK mice) was used in this study. Two months after tumor induction, mice were randomly ...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-69211 | biostudies-arrayexpress
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