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TranscriptomicsIdentification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells
Identification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells. HL60 cells were untreated, or treated with 3ug/ml of Eltrombopag for 36 hrs in RPMI with 10% FBS HL60 cells were untreated, or treated with 3ug/ml of Eltrombopag for 36 hrs in RPMI with 10% FBS
ORGANISM(S): Homo sapiens 
2012-06-24 | E-GEOD-37580 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated genes upon overexpression of HLX in wild-type hematopoietic stem cells
The goal was to study the role of Hlx in hematopoiesis. Sorted Lin-Kit+Sca-1+ cells from wild-type FVB/nJ bone marrow were infected with control (pCAD-IRES-GFP) or Hlx lentivirus (pCAD-IRES-GFP-Hlx) and cultured for 2 days in Iscove’s modified Dulbecco’s medium (IMDM) containing FBS, mIL-3, mIL-6 an...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-27938 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated genes upon shRNA-mediated knock-down of HLX in the URE leukemia cell line
To study the role of Hlx in hematopoietic differentiation and tumorigenesis, URE cells were infected with short-hairpin-containing pSIH1-H1-copGFP lentiviral vector (System Biosciences, Mountain View, CA) containing either nucleotide sequences targeting luciferase (shControl) or HLX (shHLX). After 2...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-27939 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human samples from multiple myeloma patients treated with bortezomib or dexamethasone
The aims of this study were to assess the feasibility of prospective pharmacogenomics research in multicenter international clinical trials of bortezomib in multiple myeloma and to develop predictive classifiers of response and survival with bortezomib. Patients with relapsed myeloma enrolled in pha...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9782 | biostudies-arrayexpress
TranscriptomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (expression)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-50624 | biostudies-arrayexpress
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