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TranscriptomicsGene expression analysis of diabetic kidney cortices obtained from ICAM-1 deficient mice and wild type mice.
In the present study, we aimed to determine the genes involved in inflammatory process of diabetic nephropathy. ICAM-1+/+ and ICAM-1-/- mice aged 8 weeks were divided into four groups: 1) nondiabetic ICAM-1+/+ mice (ND-WT), 2) nondiabetic ICAM-1-/- mice (ND-KO), 3) streptozotocin (STZ)-induced diab...
ORGANISM(S): Mus musculus 
2014-10-08 | E-GEOD-21390 | biostudies-arrayexpress
TranscriptomicsExpression data from cultured macrophages and osteoclasts
Osteoclastogenesis is induced by the stimulation of RANKL. In the early stage of osteoclast differentiation, the osteoclast progenitor cells are primed by M-CSF, following a tightly controlled genetic program where specific sets of genes are up-regulated by RANKL. Some of them, for instance, control...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-20850 | biostudies-arrayexpress
TranscriptomicsEST sequencing and microarray analysis of the floral transcriptome of Eustoma grandiflorum
Genome-wide DNA sequence resources are expected to enhance our understanding of the molecular basis of plant development and lead to improvements in desirable traits in horticultural crops. In this study, we sequenced 643,366 ESTs from Eustoma grandiflorum flowers using a normalised cDNA library con...
ORGANISM(S): Eustoma exaltatum subsp. russellianum 
2012-09-01 | E-GEOD-34332 | biostudies-arrayexpress
ProteomicsLFQ of Spot-Trap IP-MS from Y-79 cells expressing RD3-Spot
RD3-KO Y-79 cells and RD3-SPOT-expressing cells were fixed by adding 27 µl of 37% formaldehyde (Wako) (final: 0.1%), incubated at RT for 10 min, quenched with 1 ml of 1 M Glycine-NaOH pH 7.5 (Nacalai) (final: 100 mM) at RT for 4 min, washed with 10 ml DPBS, and stocked at -80℃ as a cell pellet. For ...
ORGANISM(S): Homo Sapiens (human) 
2024-01-27 | PXD042933 | JPOST Repository
UnknownEfficacy of luseogliflozin for renal function preservation in patients with type 2 diabetes mellitus and impaired renal function: A randomized open-label clinical trial (RESOLUTION study).
Not available
S-EPMC12679181 | biostudies-literature
TranscriptomicsSingle Cell RNA-sequencing of Pancreatic Circulating Tumor Cells
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RN...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-51372 | biostudies-arrayexpress
TranscriptomicsCD133+ cells contain cancer stem cell-like properties in Malignant Mixed Mullerian Tumor (Carcinosarcoma) of the Uterus
Cancer stem cells (CSCs) that display tumor-initiating properties have recently been identified. We herein identify and characterize CSCs in human uterine carcinosarcoma, a highly aggressive and therapy-resistant gynecologic malignancy, which is considered to be of mesodermal origin. FU-MMT-1, a c...
ORGANISM(S): Homo sapiens 
2013-02-10 | E-GEOD-27172 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Single Prostate CTCs Implicates Non-Canonical Wnt Signaling in Antiandrogen Resistance
Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone metastases is challenging, hence sampling circulating tumor cells (CTCs) may reveal drug resistance mechanisms. We established ...
ORGANISM(S): Homo sapiens 
2015-09-17 | E-GEOD-67980 | biostudies-arrayexpress
UnknownComparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction.
Not available
S-EPMC1540077 | biostudies-literature
TranscriptomicsGene expression profile of ATF6a and ATF6b knockout mice with dextran sulfate sodium (DSS)-induced colitis
To understand the role of ATF6a and ATF6b in non-canonical endoplasmic reticulum stress response pathway, we have employed whole genome microarray expression profiling to identify the genes regulated by ATF6s. WIild type or, ER stress mediators,ATF6a or ATF6b-knockout mice were treated with 3% DSS ...
ORGANISM(S): Mus musculus 
2015-02-08 | E-GEOD-35651 | biostudies-arrayexpress
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