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TranscriptomicsA genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanistically enforce and maintain the naïve T cell fate. Here we show that Id2 and Id3 suppressed the development and expansion o...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64779 | biostudies-arrayexpress
GenomicsOpposing roles of E2A and Id3 that orchestrate and enforce the naive T cell fate
It is established that E2A and its antagonist, Id3, modulate developmental progression at the pre-TCR and TCR checkpoints. Here we show at a global scale how E2A promotes commitment to the T cell lineage and how pre-TCR mediated signalling affects E2A genome-wide occupancy. We find aberrant develo...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-30518 | biostudies-arrayexpress
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
UnknownAccumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer.
Not available
S-EPMC4951683 | biostudies-literature
UnknownHic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo.
Not available
S-EPMC11497448 | biostudies-literature
UnknownDeep intronic founder mutations identified in the <i>ERCC4</i>/<i>XPF</i> gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum.
Not available
S-EPMC10318981 | biostudies-literature
UnknownEffects of laparoscopic sleeve gastrectomy on weight loss and metabolic improvement in subjects aged 65 years or older: a subanalysis of J-SMART study.
Not available
S-EPMC11769886 | biostudies-literature
UnknownCharacteristics of Childhood Onset and Post-Puberty Onset Obesity and Weight Regain after Laparoscopic Sleeve Gastrectomy in Japanese Subjects: A Subgroup Analysis of J-SMART.
Not available
S-EPMC9421694 | biostudies-literature
UnknownEstablishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan.
Not available
S-EPMC7444053 | biostudies-literature
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