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TranscriptomicsTranscription profiling of human synchronized HTC116 cells treated with DMSO or Nocodazole time course
Analysis of synchronized HCT116 cells at various time points up to 10 hours following treatment with DMSO or Nocodazole. Experiment Overall Design: HCT116 colorectal cancer cell line was obtained from the American Type Culture Collection (ATCC) and grown in McCOY’S 5A MEDIUM MODIFIED (SIGMA) with ...
ORGANISM(S): Homo sapiens 
2009-04-04 | E-GEOD-14103 | biostudies-arrayexpress
TranscriptomicsFGFR signature
Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic effic...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-73024 | biostudies-arrayexpress
TranscriptomicsExpression profiling MOLT-4 treated with MABL
Analysis of MOLT-4 cells at various time points up to 6 hours following treatment with mouse anti-CD47 antibody (MABL) and goat anti-mouse IgG (GAM) as the crosslinker of MABL. MABL induces apoptosis in CD47-positive MOLT-4 cells. Cell death signals via CD47 ligation were analyzed by using Affymetri...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-16494 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
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