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GenomicsEXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA
EXO1 has a structural role to promote the MLH1-MLH3 nuclease complex to process meiotic recombination intermediates into crossovers. The authors demonstrate that EXO1 function depends on conserved interactions with the MSH4 subunit of MSH4-MSH5, the MLH1 subunit of MLH1-MLH3, and DNA.
PRJEB88381 | ENA
UnknownEXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA.
Not available
S-EPMC12049449 | biostudies-literature
UnknownThe Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease.
Not available
S-EPMC11228845 | biostudies-literature
UnknownThe Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease.
Not available
S-EPMC10680668 | biostudies-literature
UnknownComprehensive mismatch repair gene panel identifies variants in patients with Lynch-like syndrome.
Not available
S-EPMC6687620 | biostudies-literature
UnknownTemporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions.
Not available
S-EPMC3061447 | biostudies-literature
UnknownExo1 protects DNA nicks from ligation to promote crossover formation during meiosis.
Not available
S-EPMC10153752 | biostudies-literature
UnknownExo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation.
Not available
S-EPMC7720183 | biostudies-literature
UnknownMutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.
Not available
S-EPMC6200270 | biostudies-literature
UnknownDelineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.
Not available
S-EPMC3377385 | biostudies-literature
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