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ProteomicsGenetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining the contributions of MMP12...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-05 | PXD046532 | Pride
Matrix metalloproteinase 12 Ldlr-deficient mice Cmd Mmp12 deficiency Proteomics 
GenomicsInsulin-stimulated glucose uptake in recombinant MMP12 treated 3T3-L1 cells
Insulin-stimulated glucose uptake in recombinant MMP12 treated 3T3-L1 cells
PRJNA840936 | ENA
TranscriptomicsInsulin-stimulated glucose uptake in recombinant MMP12 treated 3T3-L1 cells
Microbiota contributes to induction of type 2 diabetes by high-fat/high-sugar (HFHS), but which organs/pathways are impacted by microbiota remains unknown. Using multi-organ network and transkingdom analyses, we found that microbiota-dependent. impairment of OXPHOS /mitochondria in white adipose tis...
ORGANISM(S): Mus musculus 
2022-05-27 | GSE203489 | GEO
UnknownMicrobiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages.
Not available
S-EPMC9170383 | biostudies-literature
TranscriptomicsMicroarray analysis of Normal and MPS VII mouse aorta
Mucopolysaccharidosis VII (MPS VII) is due to mutations within the gene encoding the lysosomal enzyme beta-glucuronidase, and results in the accumulation of glycosaminoglycans. MPS VII causes aortic dilatation and elastin fragmentation. In this study we performed microarray analysis of ascending ao...
ORGANISM(S): Mus musculus 
2011-10-09 | E-GEOD-30657 | biostudies-arrayexpress
UnknownGenetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice.
Not available
S-EPMC10685620 | biostudies-literature
UnknownFibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12.
Not available
S-EPMC5362307 | biostudies-literature
UnknownLimited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12.
Not available
S-EPMC11506919 | biostudies-literature
TranscriptomicsTreatment of IMM cells with Oscillibater valericigenes
Microbiota contributes to induction of type 2 diabetes by high-fat/high-sugar (HFHS), but which organs/pathways are impacted by microbiota remains unknown. Using multi-organ network and transkingdom analyses, we found that microbiota-dependent. impairment of OXPHOS /mitochondria in white adipose tis...
ORGANISM(S): Mus musculus 
2022-05-27 | GSE203488 | GEO
TranscriptomicsEpididymal adipose tissue gene sequencing of mice on a normal diet, with or without gavage of Oscillibacter valericigenes
Paper abstract: Microbiota contribute to the induction of type 2 diabetes by high-fat/high-sugar (HFHS) diet, but which organs/pathways are impacted by microbiota remain unknown. Using multiorgan network and transkingdom analyses, we found that microbiotadependent impairment of OXPHOS/mitochondria i...
ORGANISM(S): Mus musculus 
2022-10-13 | GSE215226 | GEO
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