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TranscriptomicsA High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells
High doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. Using microarray analysis and Ingenuity Pathways AnalysisTM, we identified genes (up- or down-regulated, M-bM-^IM-%1.5 fold, P M-bM-^IM-$ 0.001), functions and signaling pathways that were altered follo...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-19477 | biostudies-arrayexpress
TranscriptomicsDistribution of Arp4 in G2/M phase
The actin-related proteins (ARPs) comprise a conserved protein family. Arp4p is found in large multisubunits of the INO80 and SWR1 chromatin remodeling complexes and in the NuA4 histone acetyltransferase complex. Here we show that arp4 (arp4S23AD159A) temperature-sensitive cells are defective in G2/...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-7276 | biostudies-arrayexpress
TranscriptomicsPOF (MO 459).BG3
modENCODE_submission_3052 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of 125 chromosomal proteins across the Drosophila melanogaster genome. The proteins under s...
ORGANISM(S): Drosophila melanogaster 
2011-03-09 | E-GEOD-27808 | biostudies-arrayexpress
TranscriptomicsMicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells
Studies of human embryonic stem cells (hESCs) commonly describe the non-functional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly present and upregulated after the DDR in hESCs but p2...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-36615 | biostudies-arrayexpress
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Recovery phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36466 | biostudies-arrayexpress
UnknownChalcogenidobis(ene-1,2-dithiolate)molybdenum(IV) complexes (chalcogenide E = O, S, Se): probing Mo≡E and ene-1,2-dithiolate substituent effects on geometric and electronic structure.
Not available
S-EPMC3168557 | biostudies-literature
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Exposure Phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36465 | biostudies-arrayexpress
TranscriptomicsRIP: miR-202 mimic-transfected HeLa cells vs. negative control
Potential miR-202 targets were identified using a targetome-wide RIP-based microarray. HeLa cells were transfected with either a miR-202 mimic or a scrambled single-stranded RNA negative control. RNA was isolated from total cell lysate prior to IP and from antibody-immobilized Protein G agarose be...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42981 | biostudies-arrayexpress
UnknownUnravelling the outcome of L-glutaminase produced by Streptomyces sp. strain 5 M as an anti-neoplasm activity.
Not available
S-EPMC11699688 | biostudies-literature
TranscriptomicsmodENCODE RNA-Seq of Drosophila cell lines Kc167, CME_W1_Cl.8+, S2-DRSC and ML-DmBG3-c2
Deep Sequencing of mRNA from the Drosophila melanogaster cell lines Kc167, CME_W1_Cl.8+, S2-DRSC and ML-DmBG3-c2. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Analysis of pol...
ORGANISM(S): Drosophila melanogaster 
2009-04-08 | E-GEOD-15596 | biostudies-arrayexpress
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