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ProteomicsQuantitative temporal proteomic analysis of modified vaccinia Ankara, a mpox vaccine
Modified vaccinia Ankara (MVA) immunisation is being deployed to curb the current outbreak of mpox in multiple countries1. Originally authorized for vaccination against smallpox, MVA is a vaccinia virus (VACV) strain that does not replicate in human cells or cause serious adverse events. Here, we co...
ORGANISM(S): Homo sapiens (Human) Modified Vaccinia Ankara virus 
2023-10-11 | PXD039034 | Pride
Modified vaccinia ankara  vaccinia virus  mpox  monkeypox virus  innate immunity  immune evasion  host-pathogen interaction  proteomics 
TranscriptomicsDiversity in the polyadenylation and decay of human cellular microRNAs during Vaccinia virus infection
Vaccinia virus (VACV) is a large cytoplasmic dsDNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. Here we use small RNA sequencing to comprehensively quantify the impact of VACV infection on the expression of endogenous small non-coding RNAs (sncRNAs)...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-54235 | biostudies-arrayexpress
TranscriptomicsModified Vaccinia virus Ankara vector induces specific cellular and humoral responses in the female reproductive tract, the main HIV portal of entry
The female reproductive tract is one of the major mucosal invasion site of HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the female reproductive tract after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a...
ORGANISM(S): Macaca fascicularis 
2017-06-09 | E-MTAB-5663 | biostudies-arrayexpress
TranscriptomicsModified Vaccinia Ankara Vector-Based Vaccine Protects Macaques from SARS-CoV-2 Infection, Immune Pathology and Dysfunction in the Lung
Study show that modified vaccinia Ankara (MVA)-based COVID-19 vaccine expressing membrane anchored pre-fusion stabilized spike (MVA/S) induces both neutralizing antibodies and CD8+ T cells in the blood and lung and protects from SARS-CoV-2 challenge. Single-cell RNA sequencing analysis of lung cells...
ORGANISM(S): Macaca mulatta 
2021-02-01 | GSE165747 | GEO
GenomicsModified Vaccinia Ankara Vector-Based Vaccine Protects Macaques from SARS-CoV-2 Infection, Immune Pathology and Dysfunction in the Lung
Modified Vaccinia Ankara Vector-Based Vaccine Protects Macaques from SARS-CoV-2 Infection, Immune Pathology and Dysfunction in the Lung
PRJNA695575 | ENA
UnknownSafety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals.
Not available
S-EPMC1892755 | biostudies-literature
UnknownRecombinant modified vaccinia virus Ankara-based malaria vaccines.
Not available
S-EPMC9491075 | biostudies-literature
TranscriptomicsMolecular and cellular dynamics in the skin, the lymph nodes and the blood of the immune response to intradermal injection of Modified Vaccinia Ankara vaccine
New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early in...
ORGANISM(S): Macaca fascicularis 
2017-12-29 | E-MTAB-5907 | biostudies-arrayexpress
UnknownNon-plaque-forming virions of Modified Vaccinia virus Ankara express viral genes.
Not available
S-EPMC7111619 | biostudies-literature
UnknownOX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs.
Not available
S-EPMC10165539 | biostudies-literature
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