Sort   by:  
 Page size 
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
GenomicsTranscriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy
Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy
PRJNA1311026 | ENA
TranscriptomicsEpigenetic therapy for Friedreich ataxia.
We set out to investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich ataxia (FRDA) and to evaluate safety and surrogate markers of efficacy in a phase I clinical trial in patients. In the neuronal cell model, H...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-65399 | biostudies-arrayexpress
GenomicsCFTR modulator therapy enhances peripheral blood monocyte contributions to immune responses in people with cystic fibrosis
CFTR modulator therapy enhances peripheral blood monocyte contributions to immune responses in people with cystic fibrosis
PRJNA623007 | ENA
GenomicsAnti-inflammatory and phosphorylation effects of CFTR modulator triple therapy in cystic fibrosis
Anti-inflammatory and phosphorylation effects of CFTR modulator triple therapy in cystic fibrosis
PRJNA1225598 | ENA
UnknownTriple immune modulator therapy for aberrant hyperinflammatory responses in severe COVID-19.
Not available
S-EPMC10139747 | biostudies-literature
TranscriptomicsTime-resolved immune dynamics in rheumatoid arthritis under methotrexate therapy
Methotrexate (MTX) serves as the primary treatment for rheumatoid arthritis (RA), though its mechanism of action is not yet fully understood. The goal of this study was to map the cellular and molecular changes triggered by MTX across different points in time. Using a prospective longitudinal design...
ORGANISM(S): Homo sapiens 
2026-07-01 | E-MTAB-17153 | biostudies-arrayexpress
GenomicsLigand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer
Glucocorticoids (GC) have been widely used as coadjuvants in the treatment of solid tumors, but GC treatment may be associated with poor pharmacotherapeutic response and/or prognosis. The genomic action of GC in these tumors is largely unknown. Here we find that dexamethasone (Dex, a synthetic GC) r...
ORGANISM(S): Homo sapiens 
2015-09-18 | E-GEOD-56022 | biostudies-arrayexpress
UnknownAnswering the call to address cystic fibrosis treatment burden in the era of highly effective CFTR modulator therapy.
Not available
S-EPMC7239731 | biostudies-literature
TranscriptomicsTranscriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy
Elexacaftor/tezacaftor/ivacaftor (ETI) CFTR modulator therapy has led to rapid and substantial improvements in cystic fibrosis (CF) airway disease. Underlying molecular and cellular mechanisms, long-term efficacy, and ability to reverse airway epithelial remodeling in established disease remain uncl...
ORGANISM(S): Homo sapiens 
2025-09-03 | GSE306517 | GEO
Sort   by:  
 Page size