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TranscriptomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (ChIP-chip)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27724 | biostudies-arrayexpress
GenomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (ChIP-seq)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27827 | biostudies-arrayexpress
TranscriptomicsDNA methylation, H3K4me2, H3K27me3, Pol2 promoter profiling during neuronal differentiation
Cellular differentiation entails loss of pluripotency and parallel gain of lineage-specific and ultimately cell-type specific characteristics. Using a murine system that progresses from stem cells to lineage-committed progenitors and further to terminally differentiated neurons we analyzed two repre...
ORGANISM(S): Mus musculus 
2008-06-04 | E-GEOD-11489 | biostudies-arrayexpress
TranscriptomicsThe Rhino-Deadlock-Cutoff complex licenses non-canonical transcription of dual-strand piRNA clusters in Drosophila
Argonaute proteins of the PIWI clade are central to transposon silencing in animal gonads. Their target specificity is defined by 22-30nt PIWI interacting RNAs (piRNAs), which mostly originate from discrete genomic loci termed piRNA clusters. Here we show that the RDC complex composed of Rhino, Dead...
ORGANISM(S): Drosophila melanogaster 
2014-06-08 | E-GEOD-55824 | biostudies-arrayexpress
TranscriptomicsAcetylation at the lateral surface of the nucleosome at lysine 64 of H3 regulates chromatin dynamics and defines transcriptionally active chromatin
Post-translational modifications of proteins have emerged as a major mechanism for regulating gene expression. Yet our understanding of how histone modifications directly affect chromatin function remains limited. Here, we investigate acetylation of histone H3 at lysine 64 (H3K64ac), a previously un...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-35355 | biostudies-arrayexpress
TranscriptomicsRelics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa
Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and modifications of histones and DNA. Neurospora crassa sports features of heterochromatin found in higher eu...
ORGANISM(S): Neurospora crassa 
2010-05-15 | E-GEOD-12690 | biostudies-arrayexpress
TranscriptomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (RNA-seq)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27843 | biostudies-arrayexpress
TranscriptomicsH3K64me3 and H3K9me3 profiling at promoters in mouse embryonic stem cells
Histone modifications are central to the regulation of all DNA-dependent processes but the repertoire of known modifications is far from complete. Lysine 64 of Histone H3 (H3K64) lies within the globular domain of H3 at a structurally important position within the nucleosome. We identify tri-methyla...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-16185 | biostudies-arrayexpress
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