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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
MetabolomicsSpatial and Untargeted Metabolomics Define Location- and Histology-Specific Metabolic Reprogramming in Colorectal Cancer

Colorectal cancer (CRC) exhibits profound molecular heterogeneity based on primary tumor location. A comprehensive understanding of the spatially resolved metabolic differences between right-sided (RCC) and left-sided (LCC) carcinomas remains elusive. Here, to eliminate the influence of inter-ind...

2026-03-24 | MTBLS13729 | MetaboLights
MetabolomicsHidden molecular clues in marine sediments revealed by untargeted mass spectrometry imaging

Mass spectrometry imaging (MSI) in sedimentary archives can produce records of molecular proxies at μm-scale resolution. For example, in annually varved sediments of the Santa Barbara Basin, such a fine resolution allows deciphering sub-annual distributions of archaeal tetraether lipids, haptophy...

2022-08-15 | MTBLS4609 | MetaboLights
MetabolomicsMolecular profiling of sponge movement reveals an ancient contractile-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

2026-08-11 | MTBLS8137 | MetaboLights
MetabolomicsGenetic mapping and molecular mechanism behind color variation in the Asian vine snake

BACKGROUND: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved.

RESULTS: We investigate color morph-enriched Asian vine snakes...

2023-02-23 | MTBLS6927 | MetaboLights
TranscriptomicsIntrinsic Gene Expression Profiles of Gliomas are a Better Predictor of Survival than Histology
Histological classification of gliomas guides treatment decisions. Because of the high interobserver variability, we aimed to improve classification by performing gene expression profiling on a large cohort of glioma samples of all histological subtypes and grades. The seven identified intrinsic mol...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-16011 | biostudies-arrayexpress
MetabolomicsHolistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging

A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histop...

2022-04-07 | MTBLS2671 | MetaboLights
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
MetabolomicsEpimedium-Derived Extracellular Vesicles Alleviate Cisplatin-induced Acute Kidney Injury: Integrated Multi-Omics Analysis and Molecular Simulations Reveal Flavonoid Interactions with PPARα
This study explores the protective effects and potential underlying mechanisms of Epimedium-derived extracellular vesicles (EpEVs) against cisplatin-induced acute kidney injury (CIAKI) in mice. EpEVs were isolated and purified via differential centrifugation combined with sucrose and iodixanol gradi...
2026-09-02 | MTBLS15534 | MetaboLights
TranscriptomicsComparative genomic hybridization of 17 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 17 Favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic D...
ORGANISM(S): Homo sapiens 
2006-05-11 | E-TABM-13 | biostudies-arrayexpress
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