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We used microarrays to analyze the role of Lin9 in gene expression. Experimental overall design: We prepared MEFs from embyos containing a conditional allele of Lin9 and a CreERT2 transgene. Transcriptional profiles of untreated and 4-OHT-treated MEFs were compared.
ORGANISM(S): Mus musculus 
Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and often associated with progression from benign to invasive, metastatic stages. Mutations inactivate tumor suppression by p53 and endow the protein with novel gain-of-function (GOF) activities that active...
ORGANISM(S): Homo sapiens 
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