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ProteomicsA mammalian transcription factor-specific peptide repository for targeted proteomics
Site-specific transcription factors (TFs) play an essential role in mammalian development and function as they are vital for the majority of cellular processes. Despite their biological importance, TF proteomic data is scarce in the literature, likely due to difficulties in detecting peptides as the...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-23 | PXD001212 | Pride
Transcription factor Repository for targeted proteomics Proteotypic peptide selection Quantitative proteomics 
ProteomicsPeroxiredoxin 1 protects telomeres from oxidative damage preserving chromosome ends for extension by telomerase
With the increase of atmospheric oxygen 2.3 billion years ago, mechanisms evolved to mitigate the toxic effects of oxygen radicals. Telomeres appear particularly susceptible to oxidative damage, which leads to cellular and organismal aging, cancer, cardiac failure and other diseases. Specific mechan...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD002626 | Pride
Peroxiredoxin 1  telomeres  oxidative damage  telomerase 
ProteomicsCharacterization of the surfaceome of the metal-reducing bacterium Desulfotomaculum reducens
Desulfotomaculum reducens strain MI-1 is a Gram-positive, sulfate-reducing bacterium also capable of reducing Fe(III). Metal reduction in Gram-positive bacteria is poorly understood. Here, we investigated Fe(III) reduction with lactate, a non-fermentable substrate, as the electron donor. Lactate con...
ORGANISM(S): Desulfotomaculum reducens (strain MI-1) 
2014-07-31 | PXD001072 | Pride
Desulfotomaculum reducens metal-reducing surfaceome 
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