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ProteomicsSingle Cell Immuno-laser Microdissection Coupled to Label-free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia
Cerebral ischemia entails rapid tissue damage in the affected brain area causing devastating neurological disorders. The use of biomarkers in stroke might have a major impact in patients’ management, both in the diagnosis and the prognosis. Thus, the analysis of the brain proteome is a straightforwa...
ORGANISM(S): Homo sapiens (Human) 
2017-12-04 | PXD003519 | Pride
Proteomics Label-free Stroke Brain ischemia Laser micro-dissection Biomarker 
ProteomicsInfluence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. One of the reasons that could explain this failure is that the animal models used to test n...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-14 | PXD032141 | Pride
Proteomics  transcriptomics  integromics  stroke  ischemic brain  mouse 
ProteomicsProtein profiling and identification of new biomarkers of brain ischemia by MALDI-imaging-mass-spectrometry
Introduction The identification of proteins involved in brain ischemia might allow the discovery of new putative biomarkers or potential therapeutic target of one of the most important neurological disorders. MALDI Imaging-Mass-Spectrometry (IMS) is a powerful technique that allows the visualization...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD003644 | Pride
Tmcao Biomarkers Brain ischemia Maldi imaging 
ProteomicsIntegrative multi-omics analysis to characterize human brain ischemia
1. Rationale: Stroke is still a major cause of death and disability worldwide. A better comprehension of stroke pathophysiology is fundamental to reduce its dramatic outcome. The use of high-throughput unbiased omics approaches, such as proteomics and transcriptomics, might aid to deepen the knowled...
ORGANISM(S): Homo sapiens (Human) 
2022-12-21 | PXD022850 | Pride
Proteomics Integrative analysis Ischemic stroke Transcriptomics 
ProteomicsIdentification of potential ischemic stroke biomarkers through a brain-based multiomics integrative approach in mice
Stroke remains a major leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures of ischemic stroke within the hyper-acute phase of the disease is still of primary interest for a real translational research on stroke diagnosis, progn...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-02 | PXD016538 | Pride
Proteomics  transcriptomics  integromics  stroke  ischemic brain  mouse 
ProteomicsCharacterization of secretomes from brain microvascular endothelial cells after ischemia
The human immortalized brain endothelial cell line hCMEC/D3 is considered an in vitro model of the blood-brain-barrier. We aimed to characterize changes in the secretome of hCMEC/D3 subjected to oxygen and glucose deprivation (OGD) by SILAC, in order to identify new proteins involved in ischemia-tri...
ORGANISM(S): Homo sapiens (Human) 
2016-01-21 | PXD002292 | Pride
Hcmec/d3 Endothelial cells Oxygen and glucose deprivation Silac Secretome 
UnknownModeling the potential efficiency of a blood biomarker-based tool to guide pre-hospital thrombolytic therapy in stroke patients.
Not available
S-EPMC10175459 | biostudies-literature
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
UnknownPhenolic Compounds Content and Genetic Diversity at Population Level across the Natural Distribution Range of Bearberry (Arctostaphylos uva-ursi, Ericaceae) in the Iberian Peninsula.
Not available
S-EPMC7570137 | biostudies-literature
UnknownAPRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.
Not available
S-EPMC9999729 | biostudies-literature
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