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no omics definedGenotyping of twenty Pseudomonas aeruginosa strains
20 P. aeruginosa strains were genotyped using a custom spotted oligo array (Ausubel P. aruginosa genotyping 4.8K v1), which included primarily oligos for genes present in strain PA14 but absent in PAO1, and oligos for genes present in PAO1 but absent in PA14 (as well as controls).
ORGANISM(S): Pseudomonas aeruginosa 
2006-10-06 | E-MEXP-824 | biostudies-arrayexpress
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
TranscriptomicsA Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases
Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 14 PCa metastases fro...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-41619 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
TranscriptomicsGenome-wide expressing profiling of nasopharyngeal carcinoma primary tumors versus non-cancerous nasopharyngeal tissues.
To explore differentially expressed genes between nasopharyngeal carcinoma (NPC) primary tumors and non-cancerous nasopharyngeal tissues, 18 NPC tissue samples versus 18 control samples were utilized to perform genome-wide expressing profiling. Consequently, 2992 genes were found to be differentiall...
ORGANISM(S): Homo sapiens 
2014-01-05 | E-GEOD-53819 | biostudies-arrayexpress
UnknownDiversity of human copy number variation and multicopy genes.
Not available
S-EPMC3020103 | biostudies-literature
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
MetabolomicsThe impact of persistent colonization by Vibrio fischeri on the metabolome of the host squid Euprymna scolopes

Associations between animals and microbes affect not only the immediate tissues where they occur, but also the entire host. Metabolomics, the study of small biomolecules generated during metabolic processes, provides a window into how mutualistic interactions shape host biochemistry. The Hawaiian...

2020-07-02 | MTBLS1186 | MetaboLights
UnknownGlobal variation in copy number in the human genome.
Not available
S-EPMC2669898 | biostudies-literature
TranscriptomicsSingle Cell Transcriptomic Analysis of Prostate Cancer Cells
The ability to interrogate circulating tumor cells (CTC) and disseminated tumor cells (DTC) is restricted by the small number detected and isolated (typically <10). We wanted to determine if a commercially available technology could provide a transcriptomic profile of a single prostate cancer (PCa)...
ORGANISM(S): Homo sapiens 
2013-02-19 | E-GEOD-38416 | biostudies-arrayexpress
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