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TranscriptomicsTranscriptome sequencing of a large human family identifies the impact of rare non-coding variants
We have combined high-quality genome sequencing and RNA-sequencing data within a 17-individual, three generation family. Using these data, we have contrasted cis-acting expression, allele-specific expression and splicing quantitative trait loci (collectively termed eQTLs) within the family to eQTLs ...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-56961 | biostudies-arrayexpress
TranscriptomicsHigh-resolution transcriptome analysis with long-read RNA sequencing
Ongoing improvements to next generation sequencing technologies are leading to longer sequencing read lengths, but a thorough understanding of the impact of longer reads on RNA sequencing analyses is lacking. To address this issue, we generated and compared two RNA sequencing datasets of differing r...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-57862 | biostudies-arrayexpress
TranscriptomicsTranscriptome Sequencing from Diverse Human Populations Reveals Differentiated Regulatory Architecture
To understand the full range of expression variation, alternative splicing, and the genetics of regulatory variation in humans, we have sequenced the genomes, exomes, and transcriptomes of 45 individuals in the Human Genome Diversity Panel (HGDP) from seven worldwide populations that span the geogra...
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-54308 | biostudies-arrayexpress
GenomicsEGAD00000000027
eQTL data for European newborns
EGAD00000000027 | EGA
GenomicsIdentification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts
MicroRNAs (miRNAs) are regulatory noncoding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Interindividual variation of the miRNA expression levels is likely to influence the expression of miRNA target genes and may therefore contribute ...
EGAS00000000056 | EGA
GenomicsGencord Data Access Committee
Data Access Committee EGAC00001000105
EGAC00001000105 | EGA
GenomicsPassive and active DNA methylation and the interplay with genetic variation in gene regulation
DNA methylation is an essential1 epigenetic mark whose role in gene regulation and its dependency on genomic sequence and environment are not yet fully understood2,3. In this study we provide novel insights into the mechanistic relationships between genetic variation, DNA methylation and transcripto...
EGAS00001000446 | EGA
Genomicsena-DATASET-GenCord2-22-05-2013-15:33:28:221-28 - samples
GENCORD2 RNA-seq BAM files using BWA
EGAD00001000425 | EGA
GenomicsGENCORD2_DNAmethylation - samples
GENCORD2 DNA methylation
EGAD00010000460 | EGA
Genomicsena-DATASET-GenCord2-27-05-2013-09:30:55:905-40 - samples
204 individuals were genotyped with the Illumina 2.5M Omni chip. Filtered genotypes were imputed into the 1000 genomes project European panel SNPs. Beagle R2 is indicated in VCF files for further filtering. See Materials and Methods in publication for details.
EGAD00001000428 | EGA
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