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TranscriptomicsGene expression from human fibroblasts
Since the initial discovery that OCT4, SOX2, KLF4 and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process. However, unlike in mouse, OCT4 has not been replaced succ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-48275 | biostudies-arrayexpress
TranscriptomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-57828 | biostudies-arrayexpress
TranscriptomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs [RNA-seq]
We compared the epigenetic status of the mutant and disease-free iPSCs at the whole genome level. Whole epigenome profiling based on trimethylated H3K4 (H3K4me3) showed concordant epigenetic remodeling in the two corrected clones when compared with two mutant iPSC clones. Examination of genome-wide ...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-57826 | biostudies-arrayexpress
GenomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs [ChIP-seq]
We compared the epigenetic status of the mutant and disease-free iPSCs at the whole genome level. Whole epigenome profiling based on trimethylated H3K4 (H3K4me3) showed concordant epigenetic remodeling in the two corrected clones when compared with two mutant iPSC clones. Examination of the trimethy...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-57827 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophaes and mast cells from Pac1+/+ versus Pac1-/- animals
This SuperSeries is composed of the following subset Series:; GSE3993: Pac1+/+ versus Pac1-/- TG-macrophages_LPS 6h; GSE3994: Pac1+/+ versus Pac1-/- BMMCs_IgE-DNP 2 h Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4014 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human major leukocyte types isolated or differentiated and stimulated by LPS, IgE, and PMA from blood to characterise their expression profiles
WArning Files GSM90663.txt and GSM90665.txt are identical. In the present study we used Affymetrix oligonucleotide microarrays to produce gene transcription profiles for the major leukocyte types in humans. This comprehensive dataset enabled us to not only establish which genes were expressed in ea...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3982 | biostudies-arrayexpress
GenomicsGenome wide association study for Bladder Cancer Risk

This study funded by the National Cancer Institute (NCI) involves conducting a genome-wide association study of common genetic variants to identify markers of susceptibility to bladder cancer.

This bladder GWAS has led to the discovery of three novel regions in the genome associated with...

phs000346.v1.p1 | EGA
UnknownA multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity.
Not available
S-EPMC8861187 | biostudies-literature
GenomicCancer Genetic Markers of Susceptibility for Bladder Cancer (CGEMS Bladder)

This study funded by the National Cancer Institute (NCI) involves conducting a genome-wide association study of common genetic variants to identify markers of susceptibility to bladder cancer.

This bladder GWAS has led to the discovery of three novel regions in the genome associated with b...

phs000346 | dbGaP
UnknownCharacterisation of the blood RNA host response underpinning severity in COVID-19 patients.
Not available
S-EPMC9288817 | biostudies-literature
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