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TranscriptomicsFgf8 E18.5 hypomorph versus control mouse fetal lungs
We set out to look for genome wide gene expression changes due to deficiency of Fgf8 in the lung. RNA from 3 lungs from each genotype (mutant and littermate wild type control) are pooled for each cDNA synthesis and hybridized to individual array for a quadruple biologic repeat of the experiment
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-22893 | biostudies-arrayexpress
UnknownBehavioural flexibility in an Arctic seabird using two distinct marine habitats to survive the energetic constraints of winter.
Not available
S-EPMC9635182 | biostudies-literature
TranscriptomicsTranscription profiling of rat eye eQTL experiment
We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian eye and to identify genetic variation relevant to human eye disease. Of >31,000 gene probes represented on an Affymetrix expression microarray...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5680 | biostudies-arrayexpress
TranscriptomicsCoordinated control of senescence by lncRNA UCA1 and a novel CAPERα/TBX3 co-repressor
Coordination of a complex series of transcriptional, structural and signaling events culminates in cellular senescence, a crucial tumor suppressor mechanism. We have discovered a repressor complex composed of TBX3 and CAPERa which functions upstream of the RB and p53 effector pathways and is require...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-76572 | biostudies-arrayexpress
TranscriptomicsMouse embryo heart, e10.5 AVC: Control vs. Tbx3 hypomorphic mutant
Transcriptional profiling of the atrioventricular canal from e10.5 mouse hearts comparing wild-type control with Tbx3 GH/N hypomorphic mutant microdissected tissue. The goal was to identify direct and indirect targets of the transcription factor Tbx3, because Tbx3 is expressed in the AVC and hypomor...
ORGANISM(S): Mus musculus 
2011-04-01 | E-GEOD-24122 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
TranscriptomicsA dynamic role of Tbx3 in the pluripotency circuitry
Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and induction of pluripotency. Henc...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-73862 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans daf-19(+) and daf-19(-) mutants
By screening for genes possessing canonical X-box sequences in promoters of three Caenorhabditis species, namely C. elegans, C. briggsae and C. remanei, we identified 93 genes (including known X-box regulated genes) that encode putative components of ciliated neurons in C. elegans and are subject to...
ORGANISM(S): Caenorhabditis elegans 
2008-06-14 | E-GEOD-6563 | biostudies-arrayexpress
UnknownA multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.
Not available
S-EPMC8742248 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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