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MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (INTERVAL study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS834 | MetaboLights
UnknownIntestinal microbes: an axis of functional diversity among large marine consumers.
Not available
S-EPMC7209056 | biostudies-literature
TranscriptomicsTranscription profiling of S. cerevisiae (budding yeast) mutants reveals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death
Changes in the transcriptome of Isc1p deficient mutants. The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resis...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-05 | E-MEXP-1136 | biostudies-arrayexpress
UnknownThe effects of challenge and threat states on performance outcomes: An updated review and meta-analysis of recent findings.
Not available
S-EPMC11869992 | biostudies-literature
UnknownNeutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth.
Not available
S-EPMC9664140 | biostudies-literature
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
UnknownEarly life stage bottleneck determines rates of coral recovery following severe disturbance.
Not available
S-EPMC11771621 | biostudies-literature
UnknownA versatile active learning workflow for optimization of genetic and metabolic networks.
Not available
S-EPMC9256728 | biostudies-literature
TranscriptomicsGenomewide methylation analysis in Silver Russell syndrome patients
Genomewide methylation analysis in Silver Russell syndrome patients compared to healthy controls Bisulphite converted DNA from the 24 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-55491 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Saccharomyces cerevisiae BY4741 wt and YDL090C Delta ram1 cells.
The goal of these experiments was to determine the global expression profile response of budding yeast to a genetic block of Farnesyl Transferase (FTase). We blocked this enzyme using cells that harbour a deletion of the RAM1 gene, which encodes one of the two subunits of FTase. We compared the cell...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-30 | E-MTAB-216 | biostudies-arrayexpress
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