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TranscriptomicsPre-B cell leukemia homeobox protein Pbx1 is associated with lupus susceptibility in mice and humans
Sle1a.1 is part of the Sle1a lupus susceptibility locus which results in the production of activated and autoreactive CD4+ T cells as well as a reduction in the peripheral regulatory T cell (Treg) pool. Sle1a.1 CD4+ T cells showed a defective response to retinoic acid (RA) expansion of TGFβ-induce...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22313 | biostudies-arrayexpress
TranscriptomicsPbx1-d Induces T cell Activation and a Decreased Apoptosis in Response to Retinoic Acids (RA)
The hypothesis was tested that the Pbx1-d isoform was responsible for the Sle1a.1 phenotypes in CD4+ T cells. Jurkat T cells were transfected with a lentiviral construct expressing Pbx1-d-GFP or control RFP. Pbx1-d over-expression reduced the percentage of late apoptotic cells in response to anti-C...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22799 | biostudies-arrayexpress
TranscriptomicsCD4+ T cell gene expression in B6 vs B6.Sle1c2 mice
Sle1c is a sublocus of the NZM2410-derived Sle1 major susceptibility locus. We have previously shown that Sle1c contributes to lupus pathogenesis by conferring CD4+ T cell-intrinsic hyperactivation and increased susceptibility to chronic graft-versus-host disease (cGVHD) that mapped to the centrome...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-31702 | biostudies-arrayexpress
TranscriptomicsCell cyclin kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1
Sle2c1 is an NZM2410-derived lupus susceptibility locus that induces an expansion of the B1a cell compartment. B1a cells have a repertoire enriched for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus. Here we showed that expression of Sle2c1 enhances NZ...
ORGANISM(S): Mus musculus 
2010-07-24 | E-GEOD-23114 | biostudies-arrayexpress
UnknownRisk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts.
Not available
S-EPMC11214995 | biostudies-literature
UnknownAntibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort.
Not available
S-EPMC9546066 | biostudies-literature
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