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TranscriptomicsRNA-SEQ of WT and iMSN-D2RKO Parkinson's mice model treated with L-dopa
We analyzed the RNA expression profiles of Parkinson's model (6-hydroxydopamine lesion, 6-OHDA) mice in two different genotypes, WT and iMSN-D2RKO mice. Mutant iMSN-D2RKO mice were generated by mating D2Rflox/flox males with D2Rflox/flox females carrying the CRE under the control of the D1 receptor ...
ORGANISM(S): Mus musculus 
2023-06-06 | E-MTAB-11848 | biostudies-arrayexpress
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [DNAse-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-50823 | biostudies-arrayexpress
TranscriptomicsPin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provide a landing pad for the peptidyl prolyl-isomerase Pin1, which in turn ...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-77482 | biostudies-arrayexpress
ProteomicsSTAT3 contributes to cisplatin resistance, modulating EMT markers and the mTOR signaling in lung adenocarcinoma cells .
Lung cancer is the second leading cause of cancer death worldwide and is strongly associated with cisplatin resistance. The transcription factor STAT3 is constitutively activated in cancer cells and coordinates critical cellular processes as survival, self-renewal, and inflammation. In several types...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025778 | Pride
Lung cancer  cisplatin  proteomics  stat3  mtor  rapamycin. 
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [ChIP-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51004 | biostudies-arrayexpress
UnknownD2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
Not available
S-EPMC9579025 | biostudies-literature
UnknownMuscari comosum L. Bulb Extracts Modulate Oxidative Stress and Redox Signaling in HepG2 Cells.
Not available
S-EPMC7830645 | biostudies-literature
UnknownFrom Batch to Continuous Flow Bioprocessing: Use of an Immobilized γ-Glutamyl Transferase from B. subtilis for the Synthesis of Biologically Active Peptide Derivatives.
Not available
S-EPMC9614966 | biostudies-literature
UnknownGenetic Signatures of Dairy Lactobacillus casei Group.
Not available
S-EPMC6218691 | biostudies-literature
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