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ProteomicsHyaluronan and gellan nanohydrogels exhibit an unexpected activity in hampering Staphylococcus epidermidis biofilm
In clinical settings, the intensive use of antibiotics, particularly in intensive care settings, leads to a significant increase in the number of bacterial species that are resistant to treatment. In this context, biofilm is a crucial virulence factor that enable bacteria to persist within the host,...
ORGANISM(S): Staphylococcus epidermidis 
2026-03-30 | PXD074516 | Pride
Nanohydrogels  staphylococcus epidermidis  anti-biofilm  polysaccharides  hyaluronic acid  gellan gum 
TranscriptomicsTranscription profiling of Arabidopsis wild type and hfr1/sics1 knock-out mutant seedlings exposed to low R/FR light
Aim of the experiment is the identification of genes differentially regulated in hfr1/sics1 seedlings relative to wild type after prolonged exposure to low R/FR. To this end, gene expression changes were analysed in Arabidopsis wild-type and hfr1/sics1 knock-out mutant seedlings exposed to low R/FR ...
ORGANISM(S): Arabidopsis thaliana 
2006-03-01 | E-MEXP-444 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis thaliana seedlings after exposure to low R/FR light for a short and a long period of time
Aim of the experiment is the identification of regulatory genes rapidly induced by low R/FR and still up-regulated after prolonged exposure to FR-rich light. To this end, gene expression changes were analysed in Arabidopsis thaliana seedlings after exposure to low R/FR light for a short and a long p...
ORGANISM(S): Arabidopsis thaliana 
2006-03-01 | E-MEXP-443 | biostudies-arrayexpress
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [ChIP-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51004 | biostudies-arrayexpress
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Homo sapiens 
2014-07-07 | E-GEOD-51011 | biostudies-arrayexpress
TranscriptomicsPin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provide a landing pad for the peptidyl prolyl-isomerase Pin1, which in turn ...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-77482 | biostudies-arrayexpress
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [DNAse-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-50823 | biostudies-arrayexpress
GenomicsGenome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo [ChIP-Seq]
The tumor suppressor p53 is a transcription factor that coordinates the cellular response to DNA damage. Here we provide an integrated analysis of p53 genomic occupancy and p53-dependent gene regulation in the splenic B and non-B cell compartments of mice exposed to whole-body ionizing radiation, pr...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-71175 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-71180 | biostudies-arrayexpress
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