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TranscriptomicsHuman lymphedema tissues exhibit an inflammatory gene expression profile
Lymphedema (LD) is characterized by the accumulation of protein-rich interstitial fluid, lipids and a significant inflammatory cell infiltrate in the limb. It causes a significant morbidity and is a common disabling disease affecting more than 150 million people worldwide, however there is no yet cu...
ORGANISM(S): Homo sapiens 
2023-06-09 | E-MTAB-13019 | biostudies-arrayexpress
TranscriptomicsApelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression in lymphed...
ORGANISM(S): Homo sapiens 
2023-10-20 | E-MTAB-13381 | biostudies-arrayexpress
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