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TranscriptomicsClassification of Myeloma Using Global MicroRNA Profiling
Myeloma is a heterogeneous disease. In this work we used global microRNA profiling to classify clinical samples from UK MRC Myeloma IX, and developed a microRNA-based M-bM-^@M-^\outcome classifierM-bM-^@M-^] for risk stratification. Global microRNA expression profiling was carried out in 163 newly d...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-41276 | biostudies-arrayexpress
TranscriptomicsA compendium of myeloma associated chromosomal copy number abnormalities and their prognostic value
To obtain a comprehensive genomic profile of presenting multiple myeloma cases we performed high resolution single nucleotide polymorphism (SNP) mapping array analysis in 114 samples alongside 258 samples analysed by U133 Plus 2.0 expression array (Affymetrix). We examined DNA copy number alteratio...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-21349 | biostudies-arrayexpress
GenomicsThis DAC is to control access to data contained within dataset EGAS00001001147, for Myeloma XI clinical trial patients.
Data Access Committee EGAC00001000307
EGAC00001000307 | EGA
TranscriptomicsGene expression in 2,3-Pentanedione Induced Bronchiolitis Oblliterans
Fibrotic and nonfibrotic bronchial tissues were collected from lungs of pentandione exposed rats by laser capture microdissection. Analogous tissue was collected from air-exposed controls. Miroarray analysis revealed a number of DEGs Male Wistar Han rats were exposed to either air or 200 ppm 2,3-pen...
ORGANISM(S): Rattus norvegicus 
2015-03-03 | E-GEOD-52761 | biostudies-arrayexpress
Genomics463 newly diagnosed patients with Multiple Myeloma underwent whole exome sequencing of tumour and peripheral blood DNA.
463 newly diagnosed patients from the UK Myeloma XI clinical trial (NCT01554852) underwent whole exome sequencing plus targeted capture of the IGH/K/L and MYC loci. 200 ng of DNA were processed using NEBNext DNA library prepartion kit and hybridised to the SureSelect Human All Exon V5 Plus. Four s...
EGAS00001001147 | EGA
GenomicsClonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include the maximisation of response and use of maintenance therapy. We used whole exome sequencing to study the genetics of paired presentati...
EGAS00001003539 | EGA
GenomicsUAMS - Myeloma Institute Data Access Committee
Data Access Committee EGAC00001000845
EGAC00001000845 | EGA
UnknownLAparoscopic Versus Abdominal hysterectomy (LAVA): protocol of a randomised controlled trial.
Not available
S-EPMC10481847 | biostudies-literature
Genomicsena-DATASET-ICR-GM-05-05-2015-22:13:47:053-131 - samples
463 newly diagnosed patients from the UK Myeloma XI clinical trial (NCT01554852) underwent whole exome sequencing plus targeted capture of the IGH/K/L and MYC loci. 200 ng of DNA were processed using NEBNext DNA library prepartion kit and hybridised to the SureSelect Human All Exon V5 Plus. Four s...
EGAD00001001358 | EGA
Genomicsena-DATASET-UAMS-17-03-2019-03:57:35:391-32 - samples
Series of 56 paired presentation, relapse and control samples from newly diagnosed, uniformly treated myeloma patients. Deep of treatment response and maintenance allocation (active observation or lenaldiomide) was determined for all. All samples underwent whole exome sequencing with additional bait...
EGAD00001004846 | EGA
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