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GenomicsChIPseq for H3K4me3 and H3K27me3 in LT-HSCs and MPPs
The distribution of H3K4- and H3K27me3 on the chromatin of mouse longterm hematopoietic stem cells and multipotent progenitor cells has been profiled by ChIP-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-10661 | biostudies-arrayexpress
TranscriptomicsATAC-seq of LT-HSCs and MPPs
The open chromatin of mouse longterm hematopoietic stem cells and multipotent progenitor cells has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9779 | biostudies-arrayexpress
TranscriptomicsATAC-seq of control and Cyp26b1KO HSCs
The open chromatin of mouse control and Cyp26b1KO longterm hematopoietic stem cells has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9778 | biostudies-arrayexpress
TranscriptomicsATAC-seq of HSCs in Vitamin A-free diet
The open chromatin of mouse longterm hematopoietic stem cells in control and vitamin A deficiency has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9780 | biostudies-arrayexpress
TranscriptomicsRNA Seq of control and Cyp26b1KO HSCs after 24h of in vitro culture and treatment
The transcriptome of Ctrl and Cyp26b1KO hematopoietic stem cells (HSC) after 24h in vitro culture upon retinoid treatment was assessed by RNAseq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9752 | biostudies-arrayexpress
TranscriptomicsRNA Seq of Mus musculus normal and Vitamin A-deficient HSCs and MPP cells
The transcriptome of Ctrl and Vitamin A-deficient longterm hematopoietic stem cells (LT-HSC) and multipotant progenitors (MPP3/4) was assessed by RNAseq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9729 | biostudies-arrayexpress
TranscriptomicsRNA Seq of 7-month old control and Cyp26b1KO LT-HSCs
The transcriptome of Ctrl and Cyp26b1KO longterm hematopoietic stem cells (LT-HSC) of 7-month old mice was assessed by RNAseq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-10659 | biostudies-arrayexpress
TranscriptomicsRNA Seq of control and Cyp26b1 knockout mouse longterm hematopoietic stem cells
The transcriptome of Ctrl and Cyp26b1KO longterm hematopoietic stem cells (LT-HSC) was assessed by RNAseq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9745 | biostudies-arrayexpress
TranscriptomicsActinomycin D-induced mitochondrial stress targets PML during NPM1c-AML therapy
Microarrays transcriptomic data analyses from acute myeloid leukemia cell line OCI-AML2 and primary acute myeloid leukemia cells treated with actinomycin D.
ORGANISM(S): Homo sapiens 
2021-05-10 | E-MTAB-10397 | biostudies-arrayexpress
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
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