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TranscriptomicsReconstruction of an integrative gene regulatory meta-network reveals cell cycle and antiviral response as major drivers of cervical cancer
Cervical cancer is the one of the most common cancer type among women worldwide, with Human Papillomavirus (HPV) playing a causal role in this disease. We applied a novel integrative approach to understand the disease process and find its major drivers. We performed a meta-analysis of gene expressi...
ORGANISM(S): Homo sapiens 
2011-12-29 | E-GEOD-26342 | biostudies-arrayexpress
TranscriptomicsThe role of immunoglobulin A
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-33884 | biostudies-arrayexpress
TranscriptomicsDisruption of transkingdom communication by antibiotics leads to immune and mitochondrial dysfunction in the gut (LMD)
We analyzed the effects of antibiotics using a popular model of gut microbiota depletion in mice by a cocktail of antibiotics. We combined intestinal transcriptome together with metagenomic analysis of the gut microbiota to develop a new bioinformatics approach that probes the links between microbia...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-60567 | biostudies-arrayexpress
Transcriptomicshuman duodenum biopsy data
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-23933 | biostudies-arrayexpress
TranscriptomicsDisruption of transkingdom communication by antibiotics leads to immune and mitochondrial dysfunction in the gut (main)
We analyzed the effects of antibiotics using a popular model of gut microbiota depletion in mice by a cocktail of antibiotics. We combined intestinal transcriptome together with metagenomic analysis of the gut microbiota to develop a new bioinformatics approach that probes the links between microbia...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-60566 | biostudies-arrayexpress
TranscriptomicsB-cell KO mice data
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Mus musculus 
2011-11-15 | E-GEOD-23573 | biostudies-arrayexpress
TranscriptomicsThe role of transcription factor Gata4
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-33885 | biostudies-arrayexpress
TranscriptomicsIn vitro knockdown of LAMP3 leads to down-regulation of interferon-inducible genes
We identified LAMP3 as a key driver gene of anti-viral subnetwork genes in cervical cancer patients. Therefore we tested this prediction using an in vitro system. This is the first direct demonstration of LAMP3 regulatory role in interferon-dependent immune response. We first pretreated HeLa cells w...
ORGANISM(S): Homo sapiens 
2011-12-29 | E-GEOD-29009 | biostudies-arrayexpress
UnknownMulti-omic network analysis identified betacellulin as a novel target of omega- 3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis
Not available
S-SCDT-10_15252-EMMM_202318367 | biostudies-other
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