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TranscriptomicsExpression data from Ezh2 epithelial knock-out mouse lungs at E14.5
Ezh2 epigenetically suppresses developmentally-regulated genes. Ezh2 is highly expressed during development, including in the lung. We knocked out Ezh2 in the developing lung epithelium using a Shh-cre driver which is active in foregut endoderm prior to lung morphogenesis. Many developmentally regul...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60660 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNAs are spatially correlated with transcription factors and regulate lung development
To identify potential biological functions for three lncRNAs (NANCI, LL12, and LL34) we used shRNAs to knockdown expression of lncRNAs in MLE12 cells, a cell resembling type two lung epithelial cells. This data set contains the microarrays looking at gene expression. We used biological triplicate fo...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-52389 | biostudies-arrayexpress
TranscriptomicsFunctional Roles of Hdac1/2 in lung development
Hdac1/2 are important epigenetic factors, yet their functional roles in specific tissues inluding lung is not determined. We used the conditional knockout model of Hdac1/2 to determine their roles in lung development. To explore the genes that are regulated by Hdac1/2 during lung development, we per...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39946 | biostudies-arrayexpress
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