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TranscriptomicsA Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases
Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 14 PCa metastases fro...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-41619 | biostudies-arrayexpress
UnknownMachine Learning Reveals Amine Type in Polymer Micelles Determines mRNA Binding, <i>In Vitro, and In Vivo</i> Performance for Lung-Selective Delivery.
Not available
S-EPMC12041957 | biostudies-literature
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
UnknownPhosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.
Not available
S-EPMC10809103 | biostudies-literature
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
UnknownIntegrating belowground recovery into tropical forest restoration design and monitoring.
Not available
S-EPMC12650528 | biostudies-literature
UnknownFluctuating optimum and temporally variable selection on breeding date in birds and mammals.
Not available
S-EPMC7116484 | biostudies-literature
TranscriptomicsSingle Cell Transcriptomic Analysis of Prostate Cancer Cells
The ability to interrogate circulating tumor cells (CTC) and disseminated tumor cells (DTC) is restricted by the small number detected and isolated (typically <10). We wanted to determine if a commercially available technology could provide a transcriptomic profile of a single prostate cancer (PCa)...
ORGANISM(S): Homo sapiens 
2013-02-19 | E-GEOD-38416 | biostudies-arrayexpress
TranscriptomicsTumor Cell Heterogeneity and Dormancy in Single Disseminated Prostate Cancer Cells
Prostate cancer (PCa) disseminated tumor cells (DTC) in the bone marrow (BM) can remain dormant for prolonged periods before recurrence. Our aim was to characterize individual prostate DTC, analyze tumor cell heterogeneity, and identify markers of tumor dormancy. Custom Agilent 44K whole human geno...
ORGANISM(S): Homo sapiens 
2014-09-16 | E-GEOD-48995 | biostudies-arrayexpress
TranscriptomicsOsteoblastic response in human bone marrow stromal cells
Our goal was to determine whether osteoblastic LuCaP 23.1 prostate cancer xenograft tumors can elicit an osteoblastic response at the gene expression level in human bone marrow stromal cells. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile bone marro...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-48907 | biostudies-arrayexpress
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