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UnknownSafety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
Not available
S-EPMC4397277 | biostudies-literature
TranscriptomicsCharacterization of an Oxaliplatin Sensitivity Predictor in a preclinical Murine Model of Colorectal Cancer
Despite advances in contemporary chemotherapeutic strategies, long term survival still remains elusive for patients with metastatic colorectal cancer. A better understanding of the molecular markers of drug sensitivity to match therapy with patient is needed to improve clinical outcomes. In this stu...
ORGANISM(S): Homo sapiens 
2012-02-17 | E-GEOD-28691 | biostudies-arrayexpress
UnknownThe mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.
Not available
S-EPMC3321858 | biostudies-literature
TranscriptomicsPancreatic Tumor vs Various Tissue Normals
Pancreatic Tumor samples from biopsy collected at different stages along with normal tissue samples from various organ sites including commercial normals arrayed on 2channel Agilent 60mer Oligo arrays (human v1 & v2), median normalized for cross comparison. Some normal samples temporarily removed to...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-11838 | biostudies-arrayexpress
TranscriptomicsA mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Igh/Myc translocations underlie both sporadic Burkitt lymphoma (BL) and the endemic clinical form affecting African children infected with malaria. However, while sporadic translocations decapitate Myc from 5' proximal regulatory elements, most endemic events occur hundreds of kilobases away from My...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-48514 | biostudies-arrayexpress
TranscriptomicsPseudo-temporal ordering of individual cells reveals regulators of differentiation
Single-cell expression profiling by RNA-Seq promises to exploit cell-to-cell variation in gene expression to reveal regulatory circuitry governing cell differentiation and other biological processes. Here, we describe Monocle, a novel unsupervised algorithm for ordering cells by progress through di...
ORGANISM(S): Homo sapiens 
2014-03-23 | E-GEOD-52529 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T-dependent and T-independent germinal center B cells
Selection of B cells subjected to hypermutation in germinal centres (GC) during T-dependent (TD) antibody responses yields memory cells and long-lived plasma cells that produce high affinity antibodies biased to foreign antigens rather than self-antigens. GC also form in T-independent (TI) responses...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8906 | biostudies-arrayexpress
TranscriptomicsMolecular Evaluation of Patient-Derived Colorectal Cancer Explants as a Pre-clinical Mouse Model of Colorectal Cancer
Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and carcinogen-induced mouse models have provided important information with regard to the mechanisms underlying the oncogenic process, xenograft models re...
ORGANISM(S): Homo sapiens 
2012-06-06 | E-GEOD-35144 | biostudies-arrayexpress
TranscriptomicsExpression Signatures Identify Origin of Primary and Therapeutic Strategies for Patients with Advanced Solid Tumors
Background: Fatal cancer is often the result of spread, or metastasis, of a cancer cell from the site of its origin to a distant anatomic site. While the metastatic process and the foreign environment of the metastatic site impact a tumorâ??s biology, we continue to determine therapy for patients ba...
ORGANISM(S): Homo sapiens 
2016-02-13 | E-GEOD-18549 | biostudies-arrayexpress
ProteomicsUbiquitin Proteomics Analysis of Systemic Sclerosis Lung Fibroblasts with or without KLHL42 knockdown
Systemic scleroderma (SSc) is an autoimmune disease which results in fibrotic production in the lung. Resultant SSC-pulmonary fibrosis is the main cause of mortality among SSc patients. From high throughput RNAi screening, we uncovered the ubiquitin E3 ligase KLHL42 as a potential pro-fibrotic media...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-14 | MSV000084800 | MassIVE
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