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TranscriptomicsMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the tumor epithelium are poorly understood. The signaling adapter p62 has been implicated as a positive regulator of epithelial tumorigenesis; however, its role in the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-55587 | biostudies-arrayexpress
TranscriptomicsPKCzeta-mediated Gaq stimulation of the ERK5 pathway is involved in cardiac hypertrophy
Background: Gq-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of cardiovascular function. Enhanced Gaq-mediated signaling plays an important role in cardiac hypertrophy and in the transition to heart failure. We have recently describ...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-29145 | biostudies-arrayexpress
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