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TranscriptomicsRNAi knock down of Sox4 in a human adenoid cystic carcinoma cell line reveals that knockdown of Sox4 expression induces apoptosis
Sox4 is upregulated in adenoid cystic carcinoma (ACC). The ACC3 cell line is the most widely available cell culture model system of this tumor type. RNAi mediated knockdown of Sox4 in ACC3 cells induces apoptosis.
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4225 | biostudies-arrayexpress
GenomicsGenetic and epigenetic characterization of adenoid cystic carcinoma
Translocation events are frequent in cancer and may create chimeric fusions or regulatory rearrangements that drive oncogene overexpression. Although regulatory rearrangements are increasingly recognized in hematopoietic and even solid tumors, the underlying mechanisms remain obscure. Here we identi...
EGAS00001001457 | EGA
Genomicsena-DATASET-MGH2-10-11-2015-05:01:11:768-248 - samples
Whole genome sequences of ACC primagrafts, Histone modification maps and transcription factor binding maps for ACC primagrafts and primary tumors. Processed ChIP-seq data is available on GEO under accession number GSE76465.
EGAD00001001662 | EGA
GenomicsDAC for ACC Study
Data Access Committee EGAC00001000376
EGAC00001000376 | EGA
TranscriptomicsExpression data from ACC xenografts and normal salivary glands
Adenoid cystic carcinoma (ACC) is an uncommon malignant neoplasm (incidence of 0.35 per 100,000) that occurs in different body sites. It most often arises in salivary glands and other secretory glands in the head and neck region. To find the gene expression signatures of ACC, we performed microarray...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-36820 | biostudies-arrayexpress
TranscriptomicsClinically significant copy number alterations and complex rearrangements of MYB and NFIB in adenoid cystic carcinoma of the head and neck
Using high-resolution, array-based comparative genomic hybridization (aCGH), we explored genomic alterations in 40 fresh-frozen ACC samples, the largest cohort to date, with the aims to: (1) identify recurrent CNAs in ACC; (2) identify novel candidate target genes; and (3) correlate recurrent CNAs w...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-34816 | biostudies-arrayexpress
TranscriptomicsIntegrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma
Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy amongst head and neck tumors that is poorly understood on a molecular level. We sought to perform a comprehensive approach for novel oncogene candidate screening under the control of promoter methylation in order to learn more about ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-25746 | biostudies-arrayexpress
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