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TranscriptomicsChromatin immunoprecipitation of yeast to identify Yap1p binding in response to hydrogen peroxide and selenite treatment
This work aimed at analysing the Yap1p genome-wide location in different physiological conditions.
ORGANISM(S): Saccharomyces cerevisiae 
2008-03-05 | E-TABM-437 | biostudies-arrayexpress
TranscriptomicsIn vivo rabbit preimplantation development
Evaluation of the transcriptomic profile of the rabbit embryo along the preimplantation period during in vivo development. Three embryonic stages were used: four cell embryos (H32 post-coïtum); morula (H58 pc) and blastocyst (H90 pc). Keywords: time course rabbit embryo 18 samples
ORGANISM(S): Oryctolagus cuniculus 
2008-11-30 | E-GEOD-12084 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response to selenite of yeast strains that are wild type or deleted for transcription factor encoding genes involved in stress responses
This work aimed at analysing the transcriptome response of S. cerevisiae strains, wild type or deleted for transcription factor encoding genes involved in stress response, to selenite (1mM), inoculated for different time periods.
ORGANISM(S): Saccharomyces cerevisiae 
2008-03-14 | E-TABM-439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary rat hippocampal culture cells overexpressing an activated form of calcineurin
Micorarray analysis was performed on RNA samples from hippocampal cultures infected with either Ad-aCaN or Ad-LacZ or uninfected. Each sample was applied to its own GeneChip (Rat RG-U34A; n=7-9 chips/group). Chips were then processed and scanned using Agilent Affymetrix GeneArray Scanner. MAS5 was u...
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1978 | biostudies-arrayexpress
TranscriptomicsAllelic expression mapping across cell lineages reveal repressor disruption among disease SNPs
Most variants associated to diseases are located in non-coding regions of the genome, and are thought to be regulatory in nature. Cis-regulatory SNPs (cis-rSNPs) impacting transcription can be identified through the mapping of differences in allelic expression (AE). We mapped common cis-rSNPs of pro...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-53837 | biostudies-arrayexpress
ProteomicsRoot membrane ubiquitinome under osmotic stress reveals specific post-translational modification patterns
Osmotic stress is detrimental for the plant which survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification (PTM) in osmotic mediated stress. Plants use the ubiquitin proteasome system to modulate protein contents required to respond to and ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-04 | PXD022249 | Pride
Post-translational modification Mass spectrometry Osmotic stress Ubiquitination Aquaporin 
GenomicsHomozygous loss-of-function variants in European cosmopolitan and isolate populations
Homozygous loss of function (HLOF) variants provide a valuable window on gene function in humans, as well as an inventory of the human genes that are not essential for survival and reproduction. All humans carry at least a few HLOF variants, but the exact number of inactivated genes that can be tole...
EGAS00001001606 | EGA
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
TranscriptomicsTwo different 4-week energy-restricted diets.
The main aim of this experiment was to investigate gene expression on human adipose tissue after two different 4-week energy-restricted diets. Our questions consisted in understanding how gene expression was linked to clinical parameters of obese patients and whether the two diets were discriminated...
ORGANISM(S): Homo sapiens 
2011-02-09 | E-GEOD-27121 | biostudies-arrayexpress
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
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