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TranscriptomicsComparison of gene expression profiles of A549 cell treated with NRF2 siRNA and control siRNA
To examine the role of NRF2 in accelerating cell proliferation and to identify the target genes responsible for this function, transcriptome analysis was performed using A549 cells, in which NRF2 is constitutively activated. NRF2 was knocked down by siRNA against NRF2, and the gene expression profil...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-28230 | biostudies-arrayexpress
TranscriptomicsMouse primary megakaryocytes, wild type & NF-E2p45-deficient
To identify p45 target genes, we conducted gene expression profiling with p45-null megakaryocytes cultured from E14.5 fetal liver. Many genes encoding membrane proteins and enzymes related to platelet function, including Txas, Glycoprotein 6 (Gp6) and Selectin P (Selp), were repressed in the absence...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-15581 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of p45-/- primary megakaryocytes and WT primary megakaryocytes
Whole livers were collected from mouse fetuses at embryonic day 13.5 (E13.5), and single-cell suspensions were prepared by successive passage through 25-gauge needles. Fetal liver cells were maintained in RPMI1640 (Wako, Osaka, Japan) supplemented with 20% charcoal-stripped fetal bovine serum (FBS),...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-35645 | biostudies-arrayexpress
TranscriptomicsGene expression comparisons of megakaryocyte-erythrocyte progenitors isolated from wild type and c-MybTG/c-MybTG mice
Transgene insertion in proximity to the c-Myb gene disrupts c-Myb expression in megakaryocyte-erythrocyte progenitors (MEPs), resulting in skewed commitment to megakaryocyte lineage. To understand the genes regulated by c-Myb at the megakaryocyte-erythrocyte bifurcation, MEPs of c-MybTG/c-MybTG mic...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-19901 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in livers caused by Atg7 and/or Nrf2 deficiency
Autophagy deficiency caused by conditional knockout of Atg7 results in severe hepatitis accompanied by abundant accumulation of p62. p62 stablizes Nrf2 by disrupting the association between Keap1 and Nrf2. To understand the pathogenesis of hepatitis under the autophagy deficiency, we examined gene ...
ORGANISM(S): Mus musculus 
2010-10-14 | E-GEOD-20415 | biostudies-arrayexpress
TranscriptomicsCompound mouse mutants of bZIP transcription factors MafG and MafK reveal a regulatory network of non-crystallin genes linled to cataract
Although majority of the genes linked to pediatric cataract exhibit lens fiber cell-enriched expression, our understanding of gene regulation in these cells is limited to function of just eight transcription factors and largely in the context of crystallins. Here, we identify small Maf transcription...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-65500 | biostudies-arrayexpress
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