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TranscriptomicsTranscription profiling of human motor cortex in sporadic amyotrophic lateral sclerosis
We used oligonucleotide microarrays to find differentially expressed genes between control subjects and those affected by sporadic amyotrophic lateral sclerosis. Experiment Overall Design: Complementary RNAs (cRNAs) labelled with Cy5-CTP (Perkin-Elmer) were synthesized from 1 µg of total RNA of eac...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4595 | biostudies-arrayexpress
GenomicsTotal RNAseq in the sporadic ALS and healthy control motor cortex
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons leading to progressive muscle weakness, wasting and paralysis that result in death within a few years from disease onset. In order to characterize RNA alterations in ...
EGAS00001004286 | EGA
TranscriptomicsHigh-frequency stimulation of the ventrolateral thalamus regulates gene expression in hippocampus, motor cortex and caudate-putamen
Transcriptional profiling of rat hippocampus comparing rats subjected to chronic (1 hour daily during 14 days) vetrolateral thalamus stimulation (DBS group) with sham operated rats (with electrode placement but without stimulation) and with naive rats. Three-condition experiment, DBS, sham and nai...
ORGANISM(S): Rattus norvegicus 
2011-06-30 | E-GEOD-25860 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of post-mortem brain cortex from healthy control patients and amyotrophic lateral sclerosis patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 (C9ORF72) gene
The purpose of this experiment was to compare differences in the transcript level between RNA samples collected from post-mortem motor cortex from healthy control patients and amyotrophic lateral sclerosis (ALS) patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading ...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-MTAB-1925 | biostudies-arrayexpress
TranscriptomicsMotor cortex after C3 lesion
Gene expression analysis of motor cortex after spinal C3 lesion Dorsal column wire knife lesions: Adult female Fischer 344 rats weighing 150-200 gm were used. Animals underwent a laminectomy at spinal level C3. Dorsal funiculus lesions were made in the middle of C3 using a Kopf microwire device (Kop...
ORGANISM(S): Rattus norvegicus 
2016-07-01 | E-GEOD-76679 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes among motor and prefrontal areas of macaque monkey neocortex
Motor-related areas of neocortex are highly differentiated into several subareas from both functional and cytoarchitectural aspects in the higher primates. To assess the molecular basis of such areal specialization, we investigated the gene expression profiles of primary motor area (M1), premotor ar...
ORGANISM(S): Macaca mulatta 
2007-08-31 | E-GEOD-8644 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis in motor and sensory cortex as a result of experimental autoimmune encephalomyelitis (EAE), a neuroinflammatory model for Multiple sclerosis.
We performed micrarrays to investigate neuronal gene expression changes during acute inflammatory CNS axon injury using the murine myelin oligodendrocyte glycoprotein 35-55 (MOG35-55)-induced experimental autoimmune encephalomyelitis (EAE) model. The present study was assigned to assess the direct a...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-47900 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis identifies the gene signature of surviving motor neurons in human SOD1-related motor neuron disease
Gene expression profiling has been performed previously on motor cortex and spinal cord homogenates and of sporadic ALS cases and controls, to identify genes and pathways differentially expressed in ALS. More recent studies have combined the use of laser capture microdissection (LCM) with gene expre...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-20589 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of the expression of neurotransmitter receptor and regulator genes in 4 week old male MeCP2 A140V mutant mouse brain cortex
The goal of this study was to identify brain cortex gene expression differences between mutant MeCP2 A140V mice and their wild type littermates.The PCR array used for these experiments was the Mouse Neurotransmitter Receptors and Regulators Array (Catalog# PAMM-060A) from SABiosciences. Mice used in...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-35772 | biostudies-arrayexpress
GenomicsCorticothalamic Neurons in Motor Cortex Have a Permissive Role in Motor Execution
Corticothalamic Neurons in Motor Cortex Have a Permissive Role in Motor Execution
PRJNA1241835 | ENA
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