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GenomicsCo-activation of GR and NF-kB leads to extensive rearrangemnet of their binding sites and target genes
Global identification of activated GR and p65 binding sites and target genes using ChIP-seq in HeLa B2 cells. generation genome-wide chromatin state-maps of GR, p65 and RNAPII in HeLa B2 cells under conditions 1) DMSO (control); 2) TA 1M-BM-5M 4hr; 3) TNFM-NM-1 10ng/ml ; 4) TA 1M-BM-5M 4hr at at th...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-24518 | biostudies-arrayexpress
GenomicsSmyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver or colon cancer development
Smyd3 is a histone methyltransferase implicated in tumorigenesis. Here we show that Smyd3 expression in mice is required but not sufficient for chemically induced liver and colon cancer formation. In these organs Smyd3 is functioning in the nucleus as a direct transcriptional activator of several ke...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-67790 | biostudies-arrayexpress
TranscriptomicsPR-SET7 inactivation causes hepatocyte necrosis and spontaneous development of hepatocellular carcinoma derived from ductal progenitor cells
PR-SET7-mediated histone-4 lysine-20 methylation has been implicated in mitotic condensation, DNA damage response and replication licencing. Here we show that PR-SET7 function in the liver is pivotal for maintaining genome integrity. Hepatocyte-specific deletion of PR-SET7 in mouse embryos resulted ...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-49555 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of two human non-small-cell lung cancer cell lines in response to SN1 methylating-agents treatment
Methylating agents of SN1 type constitute a widely used class of anticancer drugs, the effect of which on human non-small-cell lung cancer (NSCLC) has not been adequately studied. We thus studied the effect of N-methyl-N-nitrosourea (MNU), a model SN1 methylating agent, on two human NSCLC cell lines...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-65933 | biostudies-arrayexpress
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