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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the metabolic programming of GM-CSF-and M-CSF-differentiated mouse macrophages

Macrophages play a critical role in the inflammatory response and tumor development. Macrophages are primarily divided into pro-inflammatory M1-like and anti-inflammatory M2-like macrophages based on their activation status and functions. In vitro macrophage models could be derived from ...

2023-09-19 | MTBLS6502 | MetaboLights
OtherHigh-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages.
Data from ProteomeXchange, PXD ID: PXD001293. File: BMDM_2.mzml. Published as part of Proteomics. 2014 Dec 12 . From the Abstract: {{i}} Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320007638 | GPMDB
Resource Reanalysis 
TranscriptomicsGenome-wide analysis of mouse macrophages stimulated with IL-4 (bone marrow macrophages) (Affymetrix)
Analysis of alternative activation of macrophages at gene expression level. The study forms part of a wider study where we compare the effects of IL-4 in different human and mouse macrophages. Our results support the notion that in vitro culture conditions greatly affect the macrophage response to I...
ORGANISM(S): Mus musculus 
2012-09-29 | E-GEOD-35435 | biostudies-arrayexpress
ProteomicsProteomic analysis of bone marrow-derived macrophages of mice treated with recombinant Ssa1, a protein enriched in the hypoxic secretome of Candida albicans.
Bone marrow-derived macrophages from mice were treated with recombinant Ssa1, a protein enriched in the hypoxic secretome of Candida albicans.
ORGANISM(S): Mus Musculus (mouse) 
2024-01-29 | PXD046766 | JPOST Repository
TranscriptomicsBone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions
Liver macrophages play a major role in the control of infections in the liver and in the pathology associated with chronic liver diseases. It was recently shown that liver macrophages can have two different origins, however, the extent to which these populations are functionally distinct remains to ...
ORGANISM(S): Mus musculus 
2016-07-28 | E-MTAB-4954 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages infected with Leishmania amazogensis amastigotes
L. amazonensis (LV79 strain, ref.: MPRO/BR/1972/M1841) amastigotes were added or not to BALB/c mouse bone marrow-derived macrophage cultures at a multiplicity of 4 per macrophage. Parasite-harboring macrophages (samples I1 and I2) and parasite-free ones (samples (UI1 and UI2) were cultured at 34M-0C...
ORGANISM(S): Mus musculus 
2009-01-01 | E-MEXP-1595 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of mouse bone marrow-derived macrophages (BMM) to lipopolysaccharide (LPS) - Illumina arrays
These microarrays were performed for use in a genome-wide scan for LPS-regulated genes in mouse macrophages, in order to construct a list of LPS-regulated genes for detailed interrogation on custom microarrays (see GSE19490 for custom array analysis). Mouse macrophages (bone marrow-derived macrophag...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19766 | biostudies-arrayexpress
TranscriptomicsExpression Data from BALB/c and Stat6-deficient bone marrow derived macrophages (BMDM)
We used microarrays to find Stat6 dependent genes in control and IL-4 exposed bone marrow derived macrophages. Alternatively activated macrophages (AAM) accumulate in tissues during Th2-associated immune responses like helminth infections and allergic disorders. These cells possess potent inhibitor...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-20030 | biostudies-arrayexpress
TranscriptomicsLactobacillus acidophilus and Helicobacter pylori stimulation of bone marrow derived macrophage
Helicobacter pylori causes chronic gastritis and avoids elimination by the immune system of the infected host. The commensal bacterium Lactobacillus acidophilus has been reported to exert beneficial effects as a supplement during H. pylori eradication therapy. In the present study, we applied whole ...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-42622 | biostudies-arrayexpress
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