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TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
TranscriptomicsGene expression data from melanoma cell lines and melanocyte controls
The two most common melanoma histopathologic subtypes, superficial spreading (SSM) and nodular melanoma (NM), are believed to represent sequential phases of linear progression from radial to vertical growth. Studies suggest, however, that SSM and NM are biologically distinct. We utilized an integrat...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-22301 | biostudies-arrayexpress
TranscriptomicsIntegrative genomics identifies molecular alterations that differentiate superficial spreading and nodular melanoma
This SuperSeries is composed of the following subset Series: GSE22301: Gene expression data from melanoma cell lines and melanocyte controls GSE22305: Affymetrix SNP6.0 Array data for melanoma cell lines Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-22306 | biostudies-arrayexpress
TranscriptomicsIn vitro characterization of stem-like cancer cells in melanoma cell lines
Nine heterogeneous melanoma cell lines including D10 and WM115 were studied for cancer stem cell characteristics in vitro. D10 cell line was the only cell line expressing the cancer stem cell marker CD133. Thus, gene expression profiling on CD133+ and CD133- D10 cells was carried out using Affymetri...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3542 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse non-metastatic and metastatic melanoma cells with and without 5AzaCdR treatment.
Comparison of melanoma cell lineages responses to 5AzaCdR with control
ORGANISM(S): Mus musculus 
2010-09-01 | E-MEXP-2517 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human uveal melanoma cell lines 92-1, MP41 and UM22 treated with entinostat, JQ1 or DMSO
As part of the preclinical research for a recently published trial of combination therapy with the HDAC inhibitor entinostat and the PD1 inhibitor pembrolizumab, an experiment was performed to determined the influence of entinostat and the BET inhibitor JQ1 on the transcriptome of three uveal melano...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-11058 | biostudies-arrayexpress
TranscriptomicsExpression data from human metastatic melanoma cell lines
The genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, that included expression of mRNAs regulated by either transforming g...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-56717 | biostudies-arrayexpress
TranscriptomicsAffymetrix copy number data for melanoma cell line mapping
We searched for putative phenotypic and genotypic differences between primary lesions and melanoma metastasis. Therefore, we investigated melanoma cells derived either from the primary tumor or from lymph node metastasis of the same individual patient. In vitro studies revealed high migratory and an...
ORGANISM(S): Homo sapiens 
2011-04-07 | E-GEOD-22461 | biostudies-arrayexpress
TranscriptomicsLentiviral shRNA library screen to identify growth-related genes in malignant melanoma
Little is known about genes that promote melanoma cell growth and proliferation. siRNAs may be used to address the role of individual genesin these processes. RNAi library screens were used in the past to gain a comprehensive overview of all genes involved in cell growth, proliferation, migration an...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-46675 | biostudies-arrayexpress
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