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GenomicsNrf2 bindng in C2C12 myotubes
Nrf2 (NF-E2-related-factor-2) contributes to the maintenance of glucose homeostasis in vivo. Nrf2 suppresses blood glucose levels by protecting pancreatic β-cells from oxidative stress and improving peripheral tissue glucose utilization. To elucidate the molecular mechanisms by which Nrf2 contribut...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-78780 | biostudies-arrayexpress
TranscriptomicsMus musculus gene expression profiling for Wt, SKM-Tg, C and SKM-KO in Affymetrix 430PM strip arrays
We analyzed the functional role of DOR (Diabetes and Obesity Regulated gene) (also named Tp53inp2) in skeletal muscle. We show that DOR has a direct impact on skeletal muscle mass in vivo. Thus, using different transgenic mouse models, we demonstrate that while muscle-specific DOR gain-of-function r...
ORGANISM(S): Mus musculus 
2014-02-13 | E-GEOD-54917 | biostudies-arrayexpress
TranscriptomicsMus musculus gene expression profiling for Wt, SKM-Tg, C and SKM-KO in Affymetrix 430PM strip arrays
We analyzed the functional role of DOR (Diabetes and Obesity Regulated gene) (also named Tp53inp2) in skeletal muscle. We show that DOR has a direct impact on skeletal muscle mass in vivo. Thus, using different transgenic mouse models, we demonstrate that while muscle-specific DOR gain-of-function r...
ORGANISM(S): Mus musculus 
2014-02-13 | GSE54917 | GEO
TranscriptomicsInducing pluripotency from mouse somatic cells by small-molecule compounds [Phalanx Mouse OneArray]
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource for regenerative medicine. However, genetic manipulation and difficult-to-manufacture strategies used in reprogramming limit their clinical applications. Here, we show pluripotency can be induced from mous...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-48201 | biostudies-arrayexpress
TranscriptomicsDifferent expression patterns in leukemia cells caused by decreased expression of TNF-α
To design an effective antibody therapy to improve clinical outcomes in leukemia, the identification of novel cell surface antigens is needed. Herein, we demonstrate a role for transmembrane tumor necrosis factor-αin leukemia. To characterize tmTNF-α expression in acute leukemia, normal hematopoieti...
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-71459 | biostudies-arrayexpress
GenomicsMus musculus
Mus musculus gene expression profiling for Wt, SKM-Tg, C and SKM-KO in Affymetrix 430PM strip arrays
PRJNA238147 | ENA
ProteomicsPantothenate kinase 4 controls skeletal muscle substrate metabolism
Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. Exercise enhances metabolic flexibility, making it an important tool for discovering mechanisms that promote efficient energy metab...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-25 | PXD057017 | Pride
Pantothenate kinase 4 (pank4) Lipid and glucose metabolism Skeletal muscle 
TranscriptomicsThe transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles
Transcriptional microarray analysis was conducted on gastrocnemius muscle of control and PGC-1β(i)skm-/- mice one week after the last tamoxifen administration using the Affymetrix Mouse Gene 1.0 ST. each sample represent a pool of 3 different mice.
ORGANISM(S): Mus musculus 
2015-12-16 | E-GEOD-73572 | biostudies-arrayexpress
UnknownSkeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.
Not available
S-EPMC6610017 | biostudies-literature
GenomicsNrf2 bindng in C2C12 myotubes
Nrf2 (NF-E2-related-factor-2) contributes to the maintenance of glucose homeostasis in vivo. Nrf2 suppresses blood glucose levels by protecting pancreatic β-cells from oxidative stress and improving peripheral tissue glucose utilization. To elucidate the molecular mechanisms by which Nrf2 contribute...
ORGANISM(S): Mus musculus 
2016-04-06 | GSE78780 | GEO
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