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TranscriptomicsExpression data for Nonalcoholic fatty liver disease patients
Nonalcoholic fatty liver disease represents a spectrum of pathology that ranges from benign steatosis to potentially-progressive steatohepatitis and affects more than 30% of US adults. Advanced NAFLD is associated with increased morbidity and mortality from cirrhosis, primary liver cancer, cardiovas...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-49541 | biostudies-arrayexpress
TranscriptomicsHedgehog and metabolism
Deregulated accumulation of myofibroblasts (MF) is central to liver fibrosis pathogenesis, but the mechanisms controlling myofibroblast fate remain poorly understood. Here we investigated whether Hedgehog (Hh) signaling regulates MF fate by modulating MF metabolism. We performed microarrays to scree...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-34949 | biostudies-arrayexpress
TranscriptomicsMethylation profiles in non-alcoholic fatty liver disease
Background & Aims: Cirrhosis and liver cancer are potential outcomes of advanced nonalcoholic fatty liver disease (NAFLD). It is not clear what factors determine whether patients will develop advanced or mild NAFLD, limiting non-invasive diagnosis and treatment before clinical sequelae emerge. We in...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-49542 | biostudies-arrayexpress
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