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TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54644 | biostudies-arrayexpress
TranscriptomicsGenomic_analysis_of_408_myeloproliferative neoplasm(MPN)_samples
Genomic DNA of granulocytes or mononuclear cell fractions of 408 myeloproliferative neoplasm (MPN) patients was analyzed using Affymetrix Genome-Wide Human SNP 6.0 arrays
ORGANISM(S): Homo sapiens 
2011-07-01 | E-MTAB-608 | biostudies-arrayexpress
TranscriptomicsIGR_IsabellePLO_MPN_IPS
Genomic profiling of progenitor CD34+ cells and their respective induced pluripotent stem cells from MPN patients
ORGANISM(S): Homo sapiens 
2014-02-08 | E-MTAB-1494 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54645 | biostudies-arrayexpress
TranscriptomicsExpression data from osteoblastic lineage cells isolated from normal and leukemic mice
Multipotent stromal cells (MSC) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. During myeloproliferative neoplasm (MPN) development, MSCs are stimulated to overproduce functtionally altered OBC...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-48438 | biostudies-arrayexpress
GenomicsGenetic charcterization of myeloproliferative neoplasms (MPN)
Genetic charcterization of myeloproliferative neoplasms (MPN)
PRJNA1162027 | ENA
UnknownComparison of recognition of symptom burden in MPN between patient- and physician-reported assessment - an intraindividual analysis by the German Study Group for MPN (GSG-MPN).
Not available
S-EPMC11976279 | biostudies-literature
ProteomicsDevelopment of resistance to type II JAK2 inhibition in MPN depends on AXL kinase and is targetable
Purpose: Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Since clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors such as CHZ868 stabilizing inactive JAK2 and reducing MPN clones, gain interest. We studied whether MPN cells escape from type ll inh...
ORGANISM(S): Homo sapiens (Human) 
2023-11-07 | PXD039419 | Pride
: lfq Resistance Myeloproliferative neoplasms Mapk Chz868 Axl Phosphoproteomics Dda Jak2 inhibition 
GenomicsRole of DYRK1A in MPN
Role of DYRK1A in MPN
PRJNA947965 | ENA
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