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TranscriptomicsSystematic dissection of regulatory motifs in 2,000 predicted human enhancers using a massively parallel reporter assay
We employ a massively parallel reporter assay (MPRA) to measure the ex vivo activities of hundreds of K562 and HepG2 enhancers with known transcription factor motif instances. For seven selected motifs that correspond to known or predicted activators and repressors in the two cell types, we make dir...
ORGANISM(S): Escherichia coli 
2013-03-15 | E-GEOD-33367 | biostudies-arrayexpress
TranscriptomicsSystematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
We apply a massively parallel reporter assay (MPRA) that relies on mRNA and plasmid tag sequencing (Tag-Seq) to compare the regulatory activities of more than 27,000 distinct variants of two inducible enhancers in human cells: a synthetic cAMP-regulated enhancer and the virus-inducible interferon be...
ORGANISM(S): Escherichia coli 
2012-02-26 | E-GEOD-31982 | biostudies-arrayexpress
TranscriptomicsMPRA of two human and one cynomologous NPC line to assay activity of DNAse1 hypersensitive sites in the proximity of the Trnp1 gene
Homo sapiens and Macaca fascicularis neural progenitor cell lines were transduced with a lentiviral MPRA (Massively Parallel Reporter Assay) library. MPRA barcode sequencing and RNA-seq was performed on the extracted RNA. MPRA data was used to compare activity of regulatory sequences across 75 mamma...
ORGANISM(S): Macaca fascicularis 
2021-05-12 | E-MTAB-9952 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis H37Rv and the isogenic mprA::Kmr mutant
Whole genome expression analyses between wild-type Mycobacterium tuberculosis H37Rv and the isogenic mprA::Kmr mutant. Expression analyses between these strains were conducted following growth under physiological conditions, or following exposure to non-inhibitory concentrations of SDS or Triton X-...
ORGANISM(S): Mycobacterium tuberculosis 
2006-03-01 | E-MEXP-552 | biostudies-arrayexpress
UnknownDesign tools for MPRA experiments.
Not available
S-EPMC6454564 | biostudies-literature
GenomicsMPRA in primary human macrophages
MPRA in primary human macrophages
PRJNA954701 | ENA
GenomicsChamber selective enhancers identified in vivo by AAV-MPRA
Chamber selective enhancers identified in vivo by AAV-MPRA
PRJNA888110 | ENA
UnknownBest practices for perturbation MPRA-a computational evaluation framework of sequence design strategies.
Not available
S-EPMC10557651 | biostudies-literature
UnknownCombining TSS-MPRA and sensitive TSS profile dissimilarity scoring to study the sequence determinants of transcription initiation.
Not available
S-EPMC10450201 | biostudies-literature
UnknownQuASAR-MPRA: accurate allele-specific analysis for massively parallel reporter assays.
Not available
S-EPMC6049023 | biostudies-literature
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