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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
ModelsFirczuk2013 - Eukaryotic mRNA translation machinery
Firczuk2013 - Eukaryotic mRNA translation machinery This is a model of Saccharomyces cerevisiae mRNA translation which includes the initiation, elongation and termination phases. The model is for 20 condon mRNAs. The building of a multi-factor complex in initiati...
2024-09-02 | BIOMD0000000457 | BioModels
TranscriptomicsTranslation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signalling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation o...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48463 | biostudies-arrayexpress
TranscriptomicsA unifying model for mTORC1-mediated regulation of mRNA translation
Ribsome profiling analysis of mRNA translation in mouse cells under conditions of mTOR activiation or inhibition. embryonic fibroblasts from 4EBP1/2 p53 mutants treated with Torin1
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-36892 | biostudies-arrayexpress
TranscriptomicsThe ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of measuring gene expression at the level of translation. We present a protocol for genome-wide, quantitative analysis of in vivo translation by deep sequencing. This ribosome pr...
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37744 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid effect on mRNA translation in childhood acute lymphoblastic leukemia
Glucocorticoids (GCs) are a central component in treating childhood acute lymphoblastic leukemia (chALL). They mainly act via regulating gene transcription. However, control of mRNA translation by GC has never been assessed systematically. In our research, T- and precursor B-ALL cells were cultured ...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-48680 | biostudies-arrayexpress
ProteomicsRibosome quality control activity potentiates vaccinia virus protein synthesis during infection
Ribosomes are highly abundant cellular machines that perform the essential task of translating the genetic code into proteins. Cellular translation activity is finely tuned and proteostasis insults, such as those incurred upon viral infection, activate stress signaling pathways that result in transl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Vaccinia Virus Wr (ncbitaxon:10254) 
2021-01-05 | MSV000086660 | MassIVE
TranscriptomicsCircadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver [RNASeq]
Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most living organisms. Such oscillations are controlled by the interplay between the circadian clock and feeding rhythms. While rhythmic mRNA accumulation has been extensively studied, comparatively less is known ab...
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-73552 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Analysis In Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Techniques for systematically monitoring protein translation have lagged far behind methods for measuring mRNA levels. Here we present a ribosome profiling strategy, based on deep sequencing of ribosome protected mRNA fragments, that enables genome-wide investigation of translation with sub-codon re...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-12 | E-GEOD-13750 | biostudies-arrayexpress
TranscriptomicsRemodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates (part 3)
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Ago2/microRNA machinery has been shown to participate in stre...
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-44378 | biostudies-arrayexpress
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